%A Phuc Loc, Bui %A Manh Hung, Vu %A Thi Thuy, Nguyen %A Hoang Mai, Tran %A Thi Huong, Le %A Thi Hong Ngoc, Tran %A Thi Hong Khanh, Do %A Thanh Tung, Bui %D 2022 %T Screening in silico Alkaloid Compounds Inhibiting Estrogen-α Receptors Against Breast Cancer %K %X Abstract: The estrogen-α (ER-α) receptor is an important target in breast cancer therapy. Alkaloids are a class of plant extracts that have the potential to inhibit ER-α receptors. In this study, we evaluated the ability of alkaloids to inhibit ER-α receptors by molecular docking method. Based on previous publications, we collected 52 alkaloid compounds. The results showed that there were 4 compounds with stronger inhibitory effects on ER-α receptors than positive controls, which are co-crystallized ligands with 4-hydroxytamoxifen. Conducting analysis according to Lipinski's 5-criteria rule and predicting pharmacokinetic-toxicological parameters, we obtained one compound with drug-like properties is Pityriacitrin B. Therefore, this compound has the potential to develop into drugs that inhibit ER-α receptors for breast cancer treatment. Keywords: Breast cancer, ER-α, molecular docking, alkaloid, Pityriacitrin B. %U https://js.vnu.edu.vn/MPS/article/view/4426 %J VNU Journal of Science: Medical and Pharmaceutical Sciences %0 Journal Article %R 10.25073/2588-1132/vnumps.4426 %V 38 %N 3 %@ 2588-1132 %8 2022-09-23