@article{MPS, author = {Ha Thi Minh Ngoc and Tran Hoang Dat and Nguyen Bach and Vu Ngoc Ha}, title = { Efficacy of Fixed-dose Combination of Brinzolamide and Brimonidine in the Treatment of Open-Angle Glaucoma: A Systematic Review}, journal = {VNU Journal of Science: Medical and Pharmaceutical Sciences}, volume = {40}, number = {4}, year = {2024}, keywords = {}, abstract = {Objective: To systematically review the efficacy and safety of Brinzolamide/Brimonidine (BRZ/BRM) in treating open-angle glaucoma (OAG). Subjects and methods: The systematic review was conducted according to the PRISMA guidelines using three databases (Pubmed, Cochrane, and Embase) till January 2024. Results: Two randomized, triple-blind intervention studies were obtained that met the selection criteria. As a result of 3-month treatment, the fixed-dose combination drug of BRZ 10 mg/mL and BRM 2 mg/mL, twice a day, had the same effect in reducing intraocular pressure as the combination of two drugs BRZ 10 mg/mL and BRM 2 mg/mL alone, twice a day (intraocular pressure difference is -0.1 mmHg). In the two intervention and non-intervention groups, there were similarities in common adverse drug reactions and the rate of adverse events leading to treatment discontinuation. Conclusion: Using the combination of BRZ/BRM in the treatment of OAG is efficacious, safe, and could be a more appropriate treatment method than combining the two individual drugs.}, issn = {2588-1132}, doi = {10.25073/2588-1132/vnumps.4699}, url = {https://js.vnu.edu.vn/MPS/article/view/4699} }