@article{NST, author = {Nguyen Phuong and Truong Hieu and Tran Van and Tran Van and Polyakova Ivanovna and Dao Nhung and Soldatenkov A.T and To Tung and Le Anh}, title = { Synthesis of Pyridinocrownophane Derivatives}, journal = {VNU Journal of Science: Natural Sciences and Technology}, volume = {33}, number = {4}, year = {2017}, keywords = {}, abstract = {The pyridinocrownophane derivatives containing 2,6-diaryl-γ-arylpyridine subunit and the aza-14-crown-4 ether ring have been exhibit high cytotoxicity on several tumor cell lines such as Hep- G2, MCF7, FL, RD, Lu. This study continues to develop method of synthesis of new γ-(fur-2-yl)pyridinoaza-14-crown-4-ether (2), γ-(naphthalen-1-yl)pyridinoaza-14-crown-4-ether (3), γ-(thien-2-yl)pyridinoaza-17-crown-5-ether (4) and γ-(2-pyridino)pyridinoaza-17-crown-5-ether (5) based on the 1,5-bis- (2-acetylphenoxy) -3- -oxapentane (1a) and 1,8-bis- (2-acetylphenoxy) -36-dioxaoctane (1b). The structure of these derivatives has determined by 1 H NMR, HPLC-MS.}, issn = {2588-1140}, doi = {10.25073/2588-1140/vnunst.4479}, url = {https://js.vnu.edu.vn/NST/article/view/4479} }