Clinical, Paraclinical Characteristics and Treatment Response in Children with Nephritis Caused by Systemic Lupus Erythematosus

Abstract

The study describes the clinical, paraclinical characteristics and treatment response in children with nephritis caused by systemic lupus erythematosus. Subjects of study: 32 children with systemic lupus erythematosus were hospitalized from June 1, 2016 to May 30, 2017 in the Pediatrics Department, Bach Mai Hospital. Methodology: Description. Results: The average age of disease was 10.2 ± 1.5 years [22 months - 15 years]. The prevalence and incidence rates of SLE were higher in girls (88.4%) than in boys (13.6%), and girl/boy ratio was 6.4/1. Facial and peripheral edema was the most common symptom (87.5%), butterfly rash (43.7%). Skin rash and fiver were 53.1%, long fiver - 40.3% and hypertension - 37.5%. Central nervous injury was found at 12.5%. The paraclinical aspects showed that 100% of the patients were positive with the anti-nuclear antibody and the anti-double stranded DNA (anti-dsDNA) antibody. Low complement C3/C4 and nephrotic proteinuria were 93.7%, acute renal injury – 37.5%. The post 6-month treatment outcomes showed that 62.6% of the patients had complete remission and the mortality rate was 9.3% (3 patients, because of their withdrawal from treatNephritis in children, Systemic Lupus Erythematosus.ment). Conclusions: The clinical manifestations of systemic nephritis caused by lupus erythematosus in the children were severe but responded well to treatment.

 Keywords

Nephritis in children, Systemic Lupus Erythematosus.

References

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