Pham Van Dem, Nguyen Thanh Nam, Pham Trung Kien

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The study describes the clinical, paraclinical characteristics and treatment response in children with nephritis caused by systemic lupus erythematosus. Subjects of study: 32 children with systemic lupus erythematosus were hospitalized from June 1, 2016 to May 30, 2017 in the Pediatrics Department, Bach Mai Hospital. Methodology: Description. Results: The average age of disease was 10.2 ± 1.5 years [22 months - 15 years]. The prevalence and incidence rates of SLE were higher in girls (88.4%) than in boys (13.6%), and girl/boy ratio was 6.4/1. Facial and peripheral edema was the most common symptom (87.5%), butterfly rash (43.7%). Skin rash and fiver were 53.1%, long fiver - 40.3% and hypertension - 37.5%. Central nervous injury was found at 12.5%. The paraclinical aspects showed that 100% of the patients were positive with the anti-nuclear antibody and the anti-double stranded DNA (anti-dsDNA) antibody. Low complement C3/C4 and nephrotic proteinuria were 93.7%, acute renal injury – 37.5%. The post 6-month treatment outcomes showed that 62.6% of the patients had complete remission and the mortality rate was 9.3% (3 patients, because of their withdrawal from treatNephritis in children, Systemic Lupus Erythematosus.ment). Conclusions: The clinical manifestations of systemic nephritis caused by lupus erythematosus in the children were severe but responded well to treatment.


Nephritis in children, Systemic Lupus Erythematosus.


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