Effects of Carbonyl-cyanide m-chlorophenylhydrazone on Mitochondrial Function of H9C2 Cells

Ngo Thi Hai Yen, Bui Thi Van Khanh, Vu Thao Hien, To Thanh Thuy, Pham Thi Bich, Dang Thi Ha Trang, Vu Thi Thu

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Published Dec 7, 2017
DOI: https://doi.org/10.25073/2588-1132/vnumps.4095

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How to Cite
YEN, Ngo Thi Hai et al. Effects of Carbonyl-cyanide m-chlorophenylhydrazone on Mitochondrial Function of H9C2 Cells. VNU Journal of Science: Medical and Pharmaceutical Sciences, [S.l.], v. 33, n. 2, dec. 2017. ISSN 2588-1132. Available at: <https://js.vnu.edu.vn/MPS/article/view/4095>. Date accessed: 21 nov. 2024. doi: https://doi.org/10.25073/2588-1132/vnumps.4095.
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Issue
Vol 33 No 2
Section
Review Articles

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Abstract

We examined the effects of carbonyl-cyanide m-chlorophenylhydrazone (CCCP) on mitochondrial function of H9C2 cells. Composition of mitochondrial membrane lipids (cardiolipin) and mitochondrial membrane potential was analyzed by fluorescence intensity change of tetramethl rhodamine ethyl ester (TMRE) and 10-nonyl acridine orange (NAO) using the LSM800 confocal microscope. Our results showed that CCCP strongly and simultaneously affected mitochondrial structure and function of H9C2 cells.