Pham Van Dem, Nguyen Thu Huong, Nguyen Thi Thuy Lien, Nguyen Thi Kien, Thai Thien Nam, Nguyen Thi Quynh Huonh

Main Article Content


This paper describes the clinical, paraclinical features and the outcomes of cyclosporine A treatment in children with steroid resistant nephrotic syndrome. Subjects and methods: Descriptive prospective study enrolled 75 children with steroid resistant primary nephrotic syndrome, hospitalized at the Department of Nephrology-Dialysis, the Hospital of Paediatrics from January 2015 to December 2015. Results: 61.3% of the patients showed early resistance and 38.7% of the patients with late resistance. The most common clinical symptoms were edema - 100%, chronic renal failure - 12.0%, hematuria - 10.6%, and hypertension - 9.3%. A renal biopsy for 34 patients showed that 70.6% of these were with focal and segmental glomerulosclerosis (FSGS), 26.5% with minimal change disease (MCD), and 4.9% with diffuse fibrosis. After a 6-month cyclosporine A treatment, the proportion of response was 81.3%, of which, 69.3% showed complete remission and 12.0% with partial remission; but after 12 months, the given percentages gradually decreased. There were 8 end-stage renal disease patients (10.7%) died. Conclusion: Steroid resistant nephrotic syndrome in the children expressed very severe clinical symptoms and the mortality rate was high.


Steroid resistant nephrotic syndrome, end-stage renal disease


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