Nguyen Van Khanh, Doan Thi Phuong, Nguyen Thi Huyen, Nguyen Thanh Hai, Vu Thi Thanh Hang

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Abstract: Rutin, a flavonol glycoside, has been reported to have antioxidant, anti-inflammatory, antithrombotic, antineoplastic effect, and can inhibit ultraviolet radiation-induced cutaneous oxidative stress and inflammation. The oral bioavailability of Rutin is very low. Phyto-phospholipid complex (phytosomes) is helpful in enhancing oral bioavailability and transdermal permeation of Rutin. Rutin phytosomes were prepared with phosphatidylcholine (PC) and cholesterol by solvent evaporation and spray drying method. The physicochemical properties of phytosomes were evaluated using particle size analyses, polydispersity index, Zeta potential, encapsulation efficiency, furrier transformation infrared spectroscopy (FTIR), differential scanning calorimetry (DSC) and X-ray diffraction (XRD). Phytosomes with the Rutin: PC: cholesterol molar ratios of 1:1:0.2, prepared by spray drying method showed the lowest particle size (266.4 nm) and the highest encapsulation efficiency (95.61%). The results of the FT-IR, DSC and XRD studies confirmed the phyto-phospholipid complex formation.

Keywords: Rutin, Phytosomes, spray drying.


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