Bui Thanh Tung, Dang Kim Thu, Nguyen Thanh Hai, Luc Thi Thanh Hang, Nguyen Thi Trang, Bui Thi Thanh Duyen, Hoang Dinh Hoa, Nguyen Thi Minh Ly

Main Article Content


Abstract: Gastric-duodenal ulcer is one of the most common digestive disorders. Medicinal plants are often used in traditional medicine to prevent and treat symptoms such as inflammation, gastritis and gastric-duodenal ulcer. This study evaluates the protective effect of the prepared functional food from Oryza sativa L., Coix lachryma jobi L., Codonopsis javanica (Blume), Atractylodis macrocephala Koidz and Dioscorea persimilis Prain et Burkill against indomethacin-induced gastric ulceration and cysteamine-induced duodenal ulcer in rats. In the gastric lesion model, rats were divided into five groups, and were given distilled water or ranitidine (50mg/kg) or functional food (3.5 g/kg or 7g/kg) for seven days. On day 7, gastric ulceration was induced by a single intraperitoneal injection of indomethacin (30 mg/kg). In the model of duodenal ulcer, rats were also divided into 5 groups and were given distilled water, or ranitidine or functional food for seven days. On day 7, gastric ulceration was induced by a single intraperitoneal injection of cysteamine (400 mg/kg). The results show that the functional food powder had a gastroprotective effect by significantly reducing the gastric ulcer index and gastric ulcer lesions. In addition, the results also show that the functional food powder had a protective effect on the duodenum by significantly reducing the duodenal ulcer index and duodenal ulcer lesions.

Keywords: Functional food, indomethacin, cysteamine, gastric ulcer, duodenal ulcer.


[1] Chattopadhyay I, Bandyopadhyay U, Biswas K, Maity P, Banerjee RK. Indomethacin inactivates gastric peroxidase to induce reactive-oxygen-mediated gastric mucosal injury and curcumin protects it by preventing peroxidase inactivation and scavenging reactive oxygen. Free radical biology and medicine, 2006; 40: 1397-1408.
[2] Minalyan A, Gabrielyan L, Scott D, Jacobs J, Pisegna JR. The Gastric and Intestinal Microbiome: Role of Proton Pump Inhibitors. Current Gastroenterology Reports, 2017; 19: 42.
[3] Kim JW. NSAID-induced gastroenteropathy. The Korean journal of gastroenterology= Taehan Sohwagi Hakhoe chi, 2008; 52: 134-141.
[4] Wallace JL, Keenan CM, Granger DN. Gastric ulceration induced by nonsteroidal anti-inflammatory drugs is a neutrophil-dependent process. American Journal of Physiology-Gastrointestinal and Liver Physiology, 1990; 259: G462-G467.
[5] Allam MM, El-Gohary OA. Gastroprotective effect of ghrelin against indomethacin-induced gastric injury in rats: possible role of heme oxygenase-1 pathway. General physiology and biophysics, 2017; 36: 321.
[6] Miller SL, Schlesinger G. Prebiotic syntheses of vitamin coenzymes: I. Cysteamine and 2-mercaptoethanesulfonic acid (coenzyme M). Journal of molecular evolution, 1993; 36: 302-307.
[7] Dohil R, Gangoiti JA, Cabrera BL, Fidler M, Schneider JA, Barshop BA. Long-term treatment of cystinosis in children with twice-daily cysteamine. The Journal of pediatrics, 2010; 156: 823-827.
[8] Selye H, Szabo S. Experimental model for production of perforating duodenal ulcers by cysteamine in the rat. Nature, 1973; 244: 458.
[9] Warzecha Z, Ceranowicz D, Dembiński A, Ceranowicz P, Cieszkowski J, Kuwahara A, Kato I, Dembiński M, Konturek PC. Ghrelin accelerates the healing of cysteamine-induced duodenal ulcers in rats. Medical science monitor: international medical journal of experimental and clinical research, 2012; 18: BR181.
[10] Inas Z, Hala AK, Gehan HH. Gastroprotective effect of Cordia myxa L. fruit extract against indomethacin-induced gastric ulceration in rats. Life Sci J, 2011; 8: 433-445.
[11] Desai JK, Goyal RK, Parmar NS. Gastric and Duodenal Anti‐ulcer Activity of SKF 38393, a Dopamine D1‐Receptor Agonist in Rats. Journal of pharmacy and pharmacology, 1995; 47: 734-738.
[12] Abdel‐Raheem IT. Gastroprotective Effect of Rutin against Indomethacin‐Induced Ulcers in Rats. Basic & clinical pharmacology & toxicology, 2010; 107: 742-750.
[13] Szabo S, Haith LR, Reynolds ES. Pathogenesis of duodenal ulceration produced by cysteamine or propionitrile. Digestive diseases and sciences, 1979; 24: 471-477.
[14] Jeitner TM, Lawrence DA. Mechanisms for the cytotoxicity of cysteamine. Toxicological sciences, 2001; 63: 57-64.
[15] Khomenko T, Szabo S, Deng X, Ishikawa H, Anderson GJ, McLaren GD. Role of iron in the pathogenesis of cysteamine-induced duodenal ulceration in rats. American Journal of Physiology-Gastrointestinal and Liver Physiology, 2009; 296: G1277-G1286.
[16] Min B, Gu L, McClung AM, Bergman CJ, Chen M-H. Free and bound total phenolic concentrations, antioxidant capacities, and profiles of proanthocyanidins and anthocyanins in whole grain rice (Oryza sativa L.) of different bran colours. Food Chemistry, 2012; 133: 715-722.
[17] Wu T-T, Charles AL, Huang T-C. Determination of the contents of the main biochemical compounds of Adlay (Coxi lachrymal-jobi). Food chemistry, 2007; 104: 1509-1515.
[18] He J-Y, Ma N, Zhu S, Komatsu K, Li Z-Y, Fu W-M. The genus Codonopsis (Campanulaceae): a review of phytochemistry, bioactivity and quality control. Journal of natural medicines, 2015; 69: 1-21.
[19] Peng W, Han T, Xin W-B, Zhang X-G, Zhang Q-Y, Jia M, Qin L-P. Comparative research of chemical constituents and bioactivities between petroleum ether extracts of the aerial part and the rhizome of Atractylodes macrocephala. Medicinal chemistry research, 2011; 20: 146-151.
[20] Saleha S, Saidi N, Rasnovi S, Iqbalsyah TM. Nutritional Composition of Dioscorea Hispida from Different Locations around Leuser Ecosystem Area. Jurnal Natural, 2018; 18: 1-6.
[21] Sathish R, Vyawahare B, Natarajan K. Antiulcerogenic activity of Lantana camara leaves on gastric and duodenal ulcers in experimental rats. Journal of ethnopharmacology, 2011; 134: 195-197.