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Abstract: Gastric-duodenal ulcer is one of the most common digestive disorders. Medicinal plants are often used in traditional medicine to prevent and treat symptoms such as inflammation, gastritis and gastric-duodenal ulcer. This study evaluates the protective effect of the prepared functional food from Oryza sativa L., Coix lachryma jobi L., Codonopsis javanica (Blume), Atractylodis macrocephala Koidz and Dioscorea persimilis Prain et Burkill against indomethacin-induced gastric ulceration and cysteamine-induced duodenal ulcer in rats. In the gastric lesion model, rats were divided into five groups, and were given distilled water or ranitidine (50mg/kg) or functional food (3.5 g/kg or 7g/kg) for seven days. On day 7, gastric ulceration was induced by a single intraperitoneal injection of indomethacin (30 mg/kg). In the model of duodenal ulcer, rats were also divided into 5 groups and were given distilled water, or ranitidine or functional food for seven days. On day 7, gastric ulceration was induced by a single intraperitoneal injection of cysteamine (400 mg/kg). The results show that the functional food powder had a gastroprotective effect by significantly reducing the gastric ulcer index and gastric ulcer lesions. In addition, the results also show that the functional food powder had a protective effect on the duodenum by significantly reducing the duodenal ulcer index and duodenal ulcer lesions.
Keywords: Functional food, indomethacin, cysteamine, gastric ulcer, duodenal ulcer.
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