Hypolipidemic effect of ethanol extract from Mesona chinensis Benth. in high fat diet-induced obesity mice

Abstract

Mesona chiensis Benth. is a natural and safe pharmaceutical ingredient with many nutrients and special medical functions. The aim of this study was to investigate the prevention and treatment effect of ethanol extract from Mesona chiensis Benth. on the plasma lipid concentration of high fat diet-induced obesity mice. Male white mice (Mus musculus) 5 - 6 weeks of age were fed a high-fat diet including standard pellets (65% in weight) and boiled lard (35% in weight) for 6 weeks model obese mice. The study was divided into 2 periods: the prevention period for 4 weeks and the treatment period for 15 days. Prevention group (normal-weight mice) received ethanol extract of Mesona chinensis Benth. (400 mg/kg bw) and be fed a high-fat diet for 4 weeks. Treatment group (obese mice) received ethanol extract of Mesona chinensis Benth. (400 mg/kg bw) and be fed a high-fat diet for 15 days. The finding of the present investigation showed that mice fed a high-fat diet had significantly higher levels of TC, TG and TC/HDL-C compared to those in mice fed a normal diet. Body weight (bw) was significantly and positively correlated to TG (r = 0.53, P < 0.05) and TC (r = 0.33, P < 0.05) levels. After 4 weeks of receiving ethanol extract of Mesona chinensis Benth., the TG concentration and TC/HDL-C of the prevention group were significantly lower than those of the control group. After 15 days of treatment with obese mice, no statistically significant differences in blood lipid concentrations were observed compared with mice receiving fenofibrat and NaCl. In conclusion, ethanol extract of Mesona chinensis Benth. has the effect of preventing hyperlipidemia in mice fed a high-fat diet. 

Keywords

Mesona chiensis Benth., hypolipidemic, high fat diet, obesity mice.

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