Nguyen Thi Phuong Thao, Nguyen Thi Thi, Nguyen Thi Hong Hanh

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Mesona chiensis Benth. is a natural and safe pharmaceutical ingredient with many nutrients and special medical functions. The aim of this study was to investigate the prevention and treatment effect of ethanol extract from Mesona chiensis Benth. on the plasma lipid concentration of high fat diet-induced obesity mice. Male white mice (Mus musculus) 5 - 6 weeks of age were fed a high-fat diet including standard pellets (65% in weight) and boiled lard (35% in weight) for 6 weeks model obese mice. The study was divided into 2 periods: the prevention period for 4 weeks and the treatment period for 15 days. Prevention group (normal-weight mice) received ethanol extract of Mesona chinensis Benth. (400 mg/kg bw) and be fed a high-fat diet for 4 weeks. Treatment group (obese mice) received ethanol extract of Mesona chinensis Benth. (400 mg/kg bw) and be fed a high-fat diet for 15 days. The finding of the present investigation showed that mice fed a high-fat diet had significantly higher levels of TC, TG and TC/HDL-C compared to those in mice fed a normal diet. Body weight (bw) was significantly and positively correlated to TG (r = 0.53, P < 0.05) and TC (r = 0.33, P < 0.05) levels. After 4 weeks of receiving ethanol extract of Mesona chinensis Benth., the TG concentration and TC/HDL-C of the prevention group were significantly lower than those of the control group. After 15 days of treatment with obese mice, no statistically significant differences in blood lipid concentrations were observed compared with mice receiving fenofibrat and NaCl. In conclusion, ethanol extract of Mesona chinensis Benth. has the effect of preventing hyperlipidemia in mice fed a high-fat diet. 


Mesona chiensis Benth., hypolipidemic, high fat diet, obesity mice.


[1] A.D. Smith, S.P. Datta, G.H. Smith, Oxford dictionary of biochemistry and molecular biology, Oxford University Press, UK, 1997.
[2] T. Akiyama, I. Tachibana, H. Shirohara, N. Watanabe and M. Otsuki, High-fat hypercaloric diet induces obesity, glucose intolerance and hyperlipidemia in normal adult male Wistar rat, Diabetes research and clinical practice. 31 (1996) 27-35.
[3] T. Kelly, W. Yang, C.S. Chen, K. Reynolds, J. He, Global burden of obesity in 2005 and projections to 2030, International journal of obesity. 32 (2008) 1431-1437.
[4] E. Bonora, S. Kiechl, J. Willeit, F. Oberhollenzer, G. Egger, R. Bonadonna and M. Muggeo, Carotid atherosclerosis and coronary heart disease in the metabolic syndrome, Diabetes Care. 26 (2003) 1251-1257.
[5] P. Paramsothy, R. Knopp, Management of dyslipidaemias, Heart 92 (2006) 1529-1534.
[6] M.F. Asaolu, S.S. Asaolu, A.O. Oyeyemi and B.T. Aluko, Hypolipemic effects of methanolic extract of Persea americana seeds in hypercholesterolemic rats, J Med Medical Sci 1 (2010) 126-128.
[7] T. Zhou, D. Luo, X. Li and Y. Luo, Hypoglycemic and hypolipidemic effects of flavonoids from lotus (Nelumbo nuficera Gaertn) leaf in diabetic mice, Journal of Medicinal Plants Research 3 (2009) 290-293.
[8] R. Subramanian, M.Z. Asmawi and A. Sadikun, Effect of ethanolic extract of Andrographis paniculata (Burm. F.) nees on a combination of fat-fed diet and low dose streptozotocin induced chronic insulin resistance in rats, Diabetologia Croatica 37 (2008) 13-22.
[9] R. Gupta, R.S. Gupta, Effect of Pterocarpus marsupium in streptozotocin-induced hyperglycemic state in rats: comparison with glibenclamide, Diabetologia Croatica. 38 (2009) 39-45.
[10] N.S. El-Shenawy, I.M. Abdel-Nabi, Hypoglycemic effect of Cleome droserifolia ethanolic leaf extract in experimental diabetes, and on non-enzymatic antioxidant, glycogen, thyroid hormone and insulin levels, Diabetologia Croatica. 35 (2006) 15-22.
[11] J.C. Russell, S.D. Proctor, Small animal models of cardiovascular disease: tools for the study of the roles of metabolic syndrome, dyslipidemia, and atherosclerosis, Cardiovasc. Pathol. 15 (2006) 318-330.
[12] W. Yin, E. Carballo-Jane, D.G. McLaren, V.H. Mendoza, K. Gagen, N.S. Geoghagen and M. Wolff, Plasma lipid profiling across species for the identification of optimal animal models of human dyslipidemia, Journal of lipid research. 53 (2012) 51-65.
[13] Z. Zhao, Y. Shi, N. Huang, C. Fu, F. Tang, Q. Jiang, The research advances on Mesona chinensis Benth in China, Journal of Southern Agriculture. 42 (2011) 657-660.
[14] S. Hailan, H. Yingzhen, C. Jingying, Comparative analysis of amino acids content in Mesona chinensis from different producing areas, Chinese Wild Plant Resour 5 (2011) 19-23.
[15] Y.F. Liu, H.T. Xia, S.P. Yang, Quantitative Determination of Total Flavonoids in Sisal Flower by UV Spectrophotometry, Food Science. 9 (2005) 107-112.
[16] C. Chusak, T. Thilavech, S. Adisakwattana, Consumption of Mesona chinensis attenuates postprandial glucose and improves antioxidant status induced by a high carbohydrate meal in overweight subjects, The American journal of Chinese medicine. 42 (2014) 315-336.
[17] N.H. Linh, M.D. Quynh, M.T.T. Le, B.T.T. Thuy, V.T.M. Hong, N.T.H. Hanh, Effects of Mesona chinensis Benth. extract on obesity treatment in mice, Journal of Science and Technology of Thai Nguyen University. 164 (2017), 195-199 [Article in Vietnamese].
[18] T.T.C. Mai, N.T. Ha, P.T. Ngoc, Effect of green tea (Camellia sinensis) polyphenol on blood antioxydant status in streptozocin induced diabetic rats, Journal of Medical Research. 5 (2005) 27-33 [Article in Vietnamese].
[19] N.Q. Trung, P.T. Ngoc, Study on the effect of reducing dyslipidemia of mulberry leaf extract powder in dyslipidemia and diabetes white rats, Journal of Medical Research. 4 (2007) 107-115 [Article in Vietnamese].
[20] B. Enkhmaa, K. Shiwaku, T. Katsube, Mulberry (Murus alba L.) leaves and their major flavonol quercetin 3-(6-malonylglucoside) attenuate atheroscletotic lesion development in LDL recepror-deficient mice, The Journal of Nutrition. 135 (2005) 729-734.
[21] E.C. Aguilar, M.D.G.M.N. Queiroz, D.A.D. Oliveira and N.J.F.D. Oliveira, Serum lipid profile and hepatic evaluation in mice fed diet containing pequi nut or pulp (Caryocar brasiliense Camb.), Food Science and Technology. 31 (2011) 879-883.
[22] T.T.M. Loan, T.Q. Binh, Co-relation between body mass index and dyslipidemias in hypertensive patients, Medical journals Ho Chi Minh City. 13 (2009) 61-66.
[23] N.T.H. Hanh, L.T. Tuyet, D.T.A. Dao, Y. Tao, C.D. Toi, Childhood obesity is a high-risk factor for hypertriglyceridemia: a case-control study in Vietnam, Osong public health and research perspectives. 8 (2017) 138.
[24] C.T.M. Duyen, N.T.T. Huong, Hypolipidemic effect of Mikei red reishi esence caosule on tyloxapol (Triton WR-1339) – induced hyperlipidemia, Medical journals Ho Chi Minh City. 18 (2014) 62-68.
[25] D.T.A. Dao, L.T. Tuyet, N.T.H. Hanh, N.T.T. Thu, L.T. Anh, Treating mice for obesity and dyslipidemia using lotus (Neulumbo nucifera) leaf tea, Journal of Science, Hanoi National University of Education. 58 (2013) 122-131 [Article in Vietnamese].