Population Pharmacokinetic Analyses of Isoniazid in Tuberculosis Treatment: A Systematic Review

Abstract

This systematic review provides knowledge concerning population pharmacokinetics of isoniazid (INH) and identifies factors influencing INH pharmacokinetic variability. Pubmed and Embase databases were systematically searched from inception to July, 2017. The review includes 10 relevant articles from reference lists and all population pharmacokinetic studies of INH written in English, conducted in human (either healthy subjects or pulmonary tuberculosis patients). Most of the ten reviewed articles suggested a two-compartment model with first-order kinetics for INH with a transit-compartment model for absorption. The frequently reported significant predictor for INH clearance was of NAT2 acetylator types (slow/intermediate/fast), while weight was a significant covariate for INH volume of distribution (both central and peripheral). In children, enzyme maturation had a profound effect on INH clearance.

Keywords

Population pharmacokinetics, isoniazid.

References

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