Anti-inflammatory and Antioxidant Activities of Symplocos cochinchinensis (Lour.) Moore ssp. Laurina (Retz.) Nooteb Leaf Extract

Abstract

Symplocos cochinchinensis (S.  cochinchinensis) leaves have been used by Vietnamese in herbal medicines to support the treatment of infirmities. The purpose of this study was to determine some phytochemicals, assess in vitro anti-inflammatory and antioxidant capacities of
S. cochinchinensis leaf extract to provide information for further research. The study results show that S. cochinchinensis leaves contain polyphenols, flavonoids, and saponins by chemical reactions and thin layer chromatography profiling. The total polyphenol, flavonoid, and saponin contents were 517.71 ± 19.50 mg GAE/g d. w., 1.12 ± 0.01 mg QE/g d. w., and 32.18 ± 0.24 mg/g d. w., respectively. S. cochinchinensis leaf extract exhibited anti-inflammatory effect via in vitro protein denaturation inhibition, hemolysis inhibition by heat and hypotonicity with IC₅₀ values of 63.20, 36.32, and 42.55 μg/mL, respectively. S. cochinchinensis leaf extract also displayed antioxidant potential with IC₅₀ values of 189.09 μg/mL (DPPH inhibition), 60.67 μg/mL (ABTS inhibition), and 140.53 μg/mL (Reducing power). Taken together, S. cochinchinensis leaves have great potential for anti-inflammatory, antioxidant activities and some compounds in pure form should be isolated and studied.

Keywords: S. cochinchinensis leaves, anti-inflammatory activity, antioxidant activity

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