Establishing Population Pharmacokinetic Model for Pyrazinamide in Pulmonary Tuberculosis Patients

Abstract

In this study, a reasonable population pharmacokinetic model with influencing covariates for pyrazinamide was established based on the data of 129 pulmonary tuberculosis patients in 3 hospitals: Hanoi Lung Hospital, K74 Hospital, and Central Lung Hospital. Blood samples were obtained on the 10-14^th day after initiation of treatment. Time-concentration data were incorporated into the software MONOLIX 2019R2 for model building by non-linear mixed effect modeling method. The final population pharmacokinetic model is a one-compartment model, first-order absorption with lag time (K_a = 3.99 h^-1, T_lag = 0.445 h), linear elimination, volume of distribution V = 27.5 L, and clearance rate Cl = 2.65 L/h. Janmahasatian’s Fat-free mass was found to be influential to the inter-individual variability of volume of distribution and rate of clearance.

Keywords

Population pharmacokinetic, pyrazinamide, pulmonary tuberculosis, fat-free mass.

References

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