Tran Trong Bien, Pham Thi Linh Giang, Pham Thai Ha Van

Main Article Content


Tanshinones are an important lipophilic, bioactive diterpenoid group of danshen roots with many pharmacological activities. In this study, tanshinones rich extract of danshen roots, a typically valuable product of danshen, was prepared through a two-step process of extraction and purification. In which, adsorptive (non-ionic) macroporous resins were exploited in the purification step to remove impurities and enrich tanshinones. The obtained refined extract was red brownish dry powder with the following characteristics: loss on drying of 4.04 ± 0.18%, tanshinone IIA and cryptotanshinone content of 10.55 ± 0.21% and 5.78 ± 0.64%, respectively (the results met the requirements of the Tanshinones monograph in The Chinese Pharmacopoeia 2015). The overall yield of the established extraction process was 2.21 ± 0.12%, calculated by the weight of dry  extract.

Keywords: Tanshinones, danshen, macroporous resins, tanshinone IIA, cryptotanshinone.


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