Tran Trong Bien, Nguyen Van Han

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Abstract: Steviol glycosides from Stevia rebaudiana Bert., notably stevioside and rebaudioside A, are ingredients with many pharmaceutical applications. In which rebaudioside A has a uniform sweetness with no bitter aftertaste. A simple method for the simultaneous extraction of stevioside and rebaudioside A has been studied with basic steps including extracting medicinal herbs with water, removing impurities using lime milk, neutralizing with citric acid, purifying with water-saturated n-butanol, and crystallizing fractional to obtain stevioside and rebaudioside A. The spectral data of IR, MS, and NMR have demonstrated the product structure as stevioside and rebaudioside A. This result is a premise for further studies.

Keywords: Stevia rebaudiana, pharmaceutical, stevioside, rebaudioside A.