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Objectives: This study was done to describe the imaging characteristics of acute appendicitis on multislice computed tomography (MSCT) and the value of MSCT scan in the diagnosis of acute appendicitis. Methods: The study used retrospective and cross-sectional methods to analyze the results of 117 patients who were taken photos of CT at E Hospital from February 2021 to November 2021. Results: The most common age was over 50 years old, and the average age was 40.1±20.8. The ratio of male/female was 1/1.25. Locations of appendix: right iliac fossa 69.2%, posterior cecum 16.2%, pelvis 12%, subhepatic 0.9%, 1.7% in other places in the abdomen. The diameter of appendicitis was 10.48±2.5mm (the min was 5mm, the max was 18mm). The increase of diameter over 7mm accounted for 95.7%, appendiceal wall thickness ≥ 3mm had 83.8% of patients, and fat infiltration was seen in 88% of cases studied. Other signs: fecal stones 35%, fluid around appendix 7.7%, Douglas fluid 3.4%, right iliac fossa fluid 3.4%, mesenteric lymphadenopathy 25.7%. The rate of appendix rupture diagnosed by CT accounted was 4.3%. The sensitivity, accuracy, and positive diagnostic value of multislice CT in the diagnosis of acute appendicitis were 97.4%, 96.6%, and 99.1%, respectively. Conclusion: Multislice CT has a high value in the diagnosis of acute appendicitis.