Synthesis of Pichromenes, a Potential Anticancer Agent Using Organocatalyst
Main Article Content
Abstract
Abstract: Pichromene 1 is a potential anti-cancer substance that is being studied for treatment of chronic leukemia. In this paper have been developed method for synthesis of pichrmene 1 and its analogs by condensation between substituted salicylaldehyde and β-nitrostyrene derivatives under different conditions (solvent, reaction time, temperature and catalyst…). The research results showed that in toluene, at a temperature of 800C, with acid L-pipecolic as catalyst, the yield of pichromenes reached 82% after 24h.
The structure of the products was determined by the data of 1H-NMR and 13C-NMR spectroscopy.References
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