Effect of Sweet potato (Ipomoea batatas (L.) Lam) leaf extract on hypoglycaemia, blood insulin secretion, and key carbohydrate metabolic enzymes in expermentally obese and STZ-induced diabetic mice

Do Ngoc Lien, Do Van Phuc, Pham Quynh Lien, Ngo Thi Trang, Tran Trung Kien, Tran Thi Phuong Lien, Kim Dinh Tien

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Published Jun 15, 2011

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LIEN, Do Ngoc et al. Effect of Sweet potato (Ipomoea batatas (L.) Lam) leaf extract on hypoglycaemia, blood insulin secretion, and key carbohydrate metabolic enzymes in expermentally obese and STZ-induced diabetic mice. VNU Journal of Science: Natural Sciences and Technology, [S.l.], v. 27, n. 2, june 2011. ISSN 2588-1140. Available at: <https://js.vnu.edu.vn/NST/article/view/1318>. Date accessed: 15 nov. 2024.
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Vol 27 No 2
Section
Review Articles

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Abstract

Abstract. Hypolipidemic, hypoglycaemic effects of the ethyl acetate extract fraction from leaves of sweet potato (Ipomoea batatas (L) Lam.) (Convonvulaceae) in obese and streptozotocin (STZ) induced type 2 diabetic mice were demonstrated. When obese-diabetic mice was administrated orally daily by ethyl acetate fraction of  1000mg lyophilized powder/kg for 21 days, we showed that maximum hypoglycaemic(36.77%) and hypolipidemic effects, such as TC(35.18%), TG(29.17%), and LDLc(51.97%) were proven in treated mice compared to the control (untreated mice). The hypoglycaemic effects of ethyl acetate extract fraction from leaves of sweet potato so that it accelerated hexokinase activity, stimulated  insulin secretion and inhibited gluconeogenesis enzymatic activity (glucose-6-phosphatase).

Keywords: Ipomoea batatas leaf, obese mice, type 2 Diabetes mellitus, hypolipidemic and hypoglycaemic effect.

References

[1] A.H Barnett, S. Kumar. Obesity and diabetes, Wiley-Blackwell. UK(2009), 47.66
[2] P.K Mukherjee, K Maiti, K. Mukherjee, P.J. Houghton, Leads from Indian medicinal plants with hypoglycemic potentials, J. Ethnopharmocology 106 (2006) 1.
[3] S. Islam. Sweetpotato (Ipomoea batatas L. ) leaf: its potential effect on human healt and nutrition, Journal of Food Science Vol 71 (2), (2006), R13-R21.
[4] K.Srinivasan, B. Viswanad, C.L.Kaul, P. Ramanao. Combination of high fat diet fed and low dose STZ treated rat: a model for type 2 diabetes and pharmacological screenning, Pharmacological research 52 (2005) 313.
[5] S. Bhavana, S.K Satapathi, P. Roy. Hypoglycaemic and hypolipidemic effect of Aegle marmelos L. leaf extract on Streptozotocin incduced diabetic mice. Inter. J. Pharmacology (2007) 3(6) 444-452
[6] Reuter T.Y. Diet –induced models for obesity and type 2 diabetes. Drug discovery today: disease models. Vol.4 (1) (2007).
[7] S. Venkateswaran, L. Pari. Effect of Coccinia indica extract on blood glucose, insulin and key hepatic enzymes in experimental diabetes, Pharmaceutical Biology 40(3), (2002) 165.
[8] N. Brandstrup, JE. Kirk, C. Bruni, The hexokinase and phosphoglucoisomerase activities of aortic and pulmonary artery.l tissues in individuals of various ages, J.Gerontol. 12 (1957) 166.