Effect of Sweet potato (Ipomoea batatas (L.) Lam) leaf extract on hypoglycaemia, blood insulin secretion, and key carbohydrate metabolic enzymes in expermentally obese and STZ-induced diabetic mice

Do Ngoc Lien, Do Van Phuc, Pham Quynh Lien, Ngo Thi Trang, Tran Trung Kien, Tran Thi Phuong Lien, Kim Dinh Tien

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Published Jun 15, 2011

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LIEN, Do Ngoc et al. Effect of Sweet potato (Ipomoea batatas (L.) Lam) leaf extract on hypoglycaemia, blood insulin secretion, and key carbohydrate metabolic enzymes in expermentally obese and STZ-induced diabetic mice. VNU Journal of Science: Natural Sciences and Technology, [S.l.], v. 27, n. 2, june 2011. ISSN 2588-1140. Available at: <https://js.vnu.edu.vn/NST/article/view/1318>. Date accessed: 22 dec. 2024.
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Vol 27 No 2
Section
Review Articles

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Abstract

Abstract. Hypolipidemic, hypoglycaemic effects of the ethyl acetate extract fraction from leaves of sweet potato (Ipomoea batatas (L) Lam.) (Convonvulaceae) in obese and streptozotocin (STZ) induced type 2 diabetic mice were demonstrated. When obese-diabetic mice was administrated orally daily by ethyl acetate fraction of  1000mg lyophilized powder/kg for 21 days, we showed that maximum hypoglycaemic(36.77%) and hypolipidemic effects, such as TC(35.18%), TG(29.17%), and LDLc(51.97%) were proven in treated mice compared to the control (untreated mice). The hypoglycaemic effects of ethyl acetate extract fraction from leaves of sweet potato so that it accelerated hexokinase activity, stimulated  insulin secretion and inhibited gluconeogenesis enzymatic activity (glucose-6-phosphatase).

Keywords: Ipomoea batatas leaf, obese mice, type 2 Diabetes mellitus, hypolipidemic and hypoglycaemic effect.

References

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