Synthesis of Some 2-amino-4-(4’-methoxyphenyl)- 6-arylpyrimidines using Microwave-Assisted one-Pot Reaction under Solvent Free Conditions
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Abstract
Abstract: A convenient and efficient synthesis of pyrimidines through one-pot three-component reaction of p-methoxyaxetophenone, substituted benzaldehyde and guanidine hydrochloride in presence of solid sodium hydroxide is reported. The structure of obtained compounds have been confirmed by the resonance spectrum method from neuclei 1H and 13C. Obtained 2-amino-4-(4’-methoxyphenyl)-6-arylpyrimidine derivatives show pretty good antimicrobial activity.
Keywords: One-pot, microwave-assisted, 2-aminopyrimidine, solvent-free.
References
References
[1] M.A. El-Hashash, M.R. Mahhmoud and S.A. Madboli, “A facile one-pot conversion of chalcones to pyrimidine derivatives and their antimicrobial and antifungal activities”, Indian J. Chem., 32B ((=1993) 449.
[2] Anu Agarwal et al., “A small library of trisubstituted pyrimidines as antimalarial and antitubercular agents”, Bioorg.Med. Chem. Lett., 15 (2005) 5218.
[3] Barbara Orzeszko et al., “Novel adamantylated pyrimidines and their preliminary biological evaluations”, Il. Farmaco., 59 (2004) 929.
[4] Anu Agarwal, Ramesh, Ashutosh, Neena Goyal, Prem M. S. Chauhan, Suman Gupta, “Dihydropyrido[2,3-d]pyrimidines as a new class of antileishmanial agents”, Bioorg. Med. Chem., 13 (2005) 6678.
[5] B.S.Holla, M.Mahalinga, M.S.Karthikeyan, P.M.Akberali, N.S.Shetty, “Synthesis of some novel pyrazolo[3,4-d]pyrimidines derivatives as potential antimicrobial agents”, Bioorg. Med. Chem., 14 (2006) 2040.
[6] K. Suneel Kumar, A. Vamsi Kanth, K. Tatendra Reddy, G. Omprakash, “Synthesis and characterization of some novel Pyrimidines via Aldol Condensation”, J. Chem. Pharm. Res., 3(5) (2011) 234.
[1] M.A. El-Hashash, M.R. Mahhmoud and S.A. Madboli, “A facile one-pot conversion of chalcones to pyrimidine derivatives and their antimicrobial and antifungal activities”, Indian J. Chem., 32B ((=1993) 449.
[2] Anu Agarwal et al., “A small library of trisubstituted pyrimidines as antimalarial and antitubercular agents”, Bioorg.Med. Chem. Lett., 15 (2005) 5218.
[3] Barbara Orzeszko et al., “Novel adamantylated pyrimidines and their preliminary biological evaluations”, Il. Farmaco., 59 (2004) 929.
[4] Anu Agarwal, Ramesh, Ashutosh, Neena Goyal, Prem M. S. Chauhan, Suman Gupta, “Dihydropyrido[2,3-d]pyrimidines as a new class of antileishmanial agents”, Bioorg. Med. Chem., 13 (2005) 6678.
[5] B.S.Holla, M.Mahalinga, M.S.Karthikeyan, P.M.Akberali, N.S.Shetty, “Synthesis of some novel pyrazolo[3,4-d]pyrimidines derivatives as potential antimicrobial agents”, Bioorg. Med. Chem., 14 (2006) 2040.
[6] K. Suneel Kumar, A. Vamsi Kanth, K. Tatendra Reddy, G. Omprakash, “Synthesis and characterization of some novel Pyrimidines via Aldol Condensation”, J. Chem. Pharm. Res., 3(5) (2011) 234.