Study on Synthesis of Some 6-butoxy-4-(Substituted Imino Methyl)-2H-chromen-2-ones under Solvent-free Conditions
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Abstract
Abstract: The reaction of 6-butoxy-2-oxo-2H-chromen-4-carbaldehyde with some amines have been performed in microwave oven to give 6-butoxy-4-(substituted imino)methyl)-2H-chromen-2-ones. This method offers several advantages such as fast reaction rate and pretty high selectivity and efficiency. The structure of these compounds have been proved by the infrared spectoscopic and resonnace spectrum method from 1H and 13C. The biological activity of the synthetic compounds were also surveyed and the result shows that they have rather good antimicrobial activity against Candida albicans.
Keywords: Chromene, microwave-assisted, antibacterial, antifungal.
References
References
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[1] J. H. Pandya and K. J. Ganatra., “Synthesis, Characterization And Biological Evaluation Of Bis-Bidentate Schiff Base Metal Complexes, Inorganic Chemistry”, An Indian Journal., 3(3), (2008) 182.
[2] S. G. Naruka and S. S. Mahajan., “Conventional and microwave assisted synthesis and QSAR studies of coumarylchancones as potent antimicrobial agents”, International Journal of Research in Farmacy and Chemistry., 1(4), (2011) 2231.
[3] Keahav C. Patel and HimanShu D. Patel, “Synthesis and Biological Evaluation of Coumarinyl Sydnone Derivatives”, E-Journal of Chemistry., 8(1) (2011) 113.
[4] Vahid Vahabi and Farhad Hatamjafari, “Microwave Assisted Convenient One-Pot Synthesis of Coumarin Derivatives via Pechmann Condensation Catalyzed by FeF3 under Solvent-Free Conditions and Antimicrobial Activities of the Products”, J. Molecules., 19 (2014) 13093.
[5] Gayathri Rajamanickam, Suresh Selvaraj, and Thirumurthy Rajendran, “Synthesis, characterization and pharmacological evaluation of some potent 2-(substituted phenylimino) quinoxaline-3-one for their analgesic activity, Journal of Chemical and Pharmaceutical Research., 7(7) (2015) 961.