Le The Duan, Nguyen Dinh Thanh, Nguyen Thi Thanh, Hoang Thai Vu, Nguyen Thi Minh Nguyet, Le Thi Hoai, Nguyen Thi Thu Ha, Tran Thi Thanh Van

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Some different substituted 4-methylquinolin-2(1H)-ones have been synthesized by closing corresponding (un)substituted acetoacetanildes in the presence of ionic liquid [Bmim]OH. Obtained quinolines were conveted to its 2-chloro derivatives by reaction with POCl3. Some compounds of substituted tetrazolo[1,5-a]quinolines were synthesized by acting these 2-chloro derivatives with sodium azide in DMF as solvent. The structures of obtained compounds have been confirmed by using spectroscopic methods (IR, NMR and MS)

Keywords: Knorr synthesis, 4-methylquinolin-2(1H)-ones, ionic liquid, sodium azido


[1] Heeb S., Fletcher M.P., Chhabra S.R., Diggle S.P., Williams P., Cámara M., “Quinolones: from antibiotics to autoinducers”, FEMS Microbiology Reviews, 35(2), (2011) 247.
[2] Acar J.F., Goldstein F.W. “Trends in bacterial resistance to fluoroquinolones”, Clinical Infectious Diseases, 24 (Suppl. 1), (1997) S67.
[3] Ismail M.M., Abass M. and Hassan M.M. “Chemistry of Substituted Quinolinones. Part VI.† Synthesis and Nucleophilic Reactions of 4-Chloro-8-methylquinolin-2(1H)-one and its Thione Analogue”, 5, (2000) 1224.
[4] Welton T., “Room-Temperature Ionic Liquids. Solvents for Synthesis and Catalysis”, Chemical Reviews, 99, (1999) 2071.
[5] Nguyen Dinh Thanh, Le The Hoai, Nguyen Thi Kim Giang and Nguyen Van Quoc , “Ionic Liquids as Catalyst for Synthesis of Some Aromatic Peracetylated N-(β-D-Glucopyranosyl)Thiosemicarbazones”, Current Organic Synthesis, 13(5), (2016) 767.
[6] Le The Duan, Nguyen Dinh Thanh, Tran Thi Thanh Van, Luu Son Quy, Doan Thi Hien, Pham Thi Anh, “Study on synthesis of some substituted 4-azido-2-methylquinolines from 4-hydroxy-2-methyl-4-(1H)-quinolin-4-ones”, Vietnam Jourrnal of Chemistry, 2E (55), (2017) 161