Primary study on the response of Constitutive Androstane Receptor with Gynostemma pentaphyllum extract
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Abstract
Diabetes is a group of metabolic disorders with dangerous complications. It is a concern of the human society. In addition to diabetic therapiesby insulin treatments, pharmacology and diet, many medical plants also were used in supporting for treatment. Among them, Gynostemma pentaphyllum is known as a valuable medicinal plant that supports the treatment of diabetes, regulates blood pressure and reduces blood fats used in the form of tea or tablets. Recent studies have shown that the Androstane Constitutive Receptor (CAR) is a xenosensor for many kinds of xenobiotics, which play an important role in improving diabetes and obesity. Therefore, this study was conducted to investigate the CAR response with Gynostemma pentaphyllum extract, in order to understanding on the role of CAR in diabetes improvement with this extract. The primary results showed that the expression of CAR and its target gene (CYP2B6) were enhanced when treated with Gynostemma pentaphyllum extract.
References
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