Assess the status of exposure workers to benzene, toluene by analysis the metabolites products in the urine
Main Article Content
Abstract
Workers in the paint and shoe industries often have to exposure with benzene, toluene. The goal of this study was to assess worker exposure levels with benzene, toluene, we have analysised their metabolites in urine by HPLC method and GC method. Hippuric acid and o-cresol has been used as a toluene exposure biomarker, trans trans muconic aicd (TT-MA) and phenol has been used as a benzene exposure biomarker. Results showed that 1.05 % of the study subjects had phenol concentration in urine exceeded limit value allowed, 13.68 % of the study subjects had TT-MA concentration in urine exceeded ACGIH’s limit values allowed (≥ 0.5 mg/g creatinine). There are not any study subjects TT-MA concentration in urine exceeded Vietnam’s limit values allowed (≥ 0.5 g/g creatinine). Assess the level of exposure to toluene, results analysis hipuric acid in urine showed that the hippuric acid concentrations below the maximal biologic permissible level, but there are 37.89 % of the study subjects had o-crsol concentration in urine exceeded ACGIH’s limit values allowed and Vietnam’s limit values allowed. This results suggest a need for a revision of the TT-MA concentration limit value in urine. Assess the level of exposure to toluene should use the o-cresol index to protect workers.
References
[2]..American Conference of Governmental Industrial Hygienists. Benzene. In: Documentation of the Threshold Limit Vales and Biological Exposure Indices, 7th edition. ACGIH, Cincinnati OH (2001).
[3] Thông tư 28/2016/TT-BYT ngày 30/6/2016 Thông tư hướng dẫn quản lý bệnh nghề nghiệp được hưởng bảo hiểm xã hội.
[4]..American Conference of Governmental Industrial Hygienists. Toluene. In: Documentation of the Threshold Limit Vales and Biological Exposure Indices, 7th edition. ACGIH, Cincinnati OH (2001).
[5]..American Conference of Industrial Hygienists –ACGIH, Threshold Limit Value for Chemical Substances and Physical Agents and Biological Exposure Indices, Signature Publication, ISBN: 978-1-607260-85-1 @ 2016 (Pages: 112;118).
[6]..American Conference of Industrial Hygienists –ACGIH, Guide to Occupational exposure value, Signature publication, ISBN: 978-1-607260-86-8 @2016 (Pages: time.
[9] Dong HY., Mi YL., Yong LW., Rapid HPLC Method for the simultaneous determination of eight urinary metabolites of Toluene, Xylene and Styrene, Kanalytical science & technology Vol. 25 (6), 460-466, 2012.
[10]..https://www.cdc.gov/niosh/docs/2003-154/ pdfs/ 8305.pdf.
[11] Quyết định 3733/2002/QĐ-BYT về việc ban hành 21 tiêu chuẩn vệ sinh lao động, 05 nguyên tắc và 07 thông số vệ sinh lao động.
[12]..Viện Y học lao động và Vệ sinh môi trường, Thường quy kỹ thuật y học lao động vệ sinh môi trường sức khỏe trường học, NXB Y học 2002.