Nguyen Phu Hung, Luu Thi Binh, Le Thi Thanh Huong, Diep Thi Huong Giang

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Abstract: All-trans retinoic acid (ATRA) plays an important role in many cellular processes and is a potentially promising substance for cancer therapy. The self-renewal, a prominent feature of cancer stem cells, is tightly controlled by a number of specific genes and is mediated by the cell signaling pathways. The Notch signal pathway has been shown to be one of the few major molecular signaling pathways of cancer stem cells, which regulates the self-renewal and survival of cancer stem cells. This study shows that ATRA reduced the expression of important genes involved in self-renewal of cells, including Sox2, KLF4, DMNT1 and MYC as well as TBGUT markers such as CD24, MUC1 and CD90. Furthermore, it is indicated that the ATRA-induced expression of self-renewal genes and cancer stem cell markers of gastric cancer stem cells can be mediated by the regulation of the Notch signaling pathway.

Keywords: All-trans retinoic acid, gastric cancer stem cell, Notch signaling pathway.


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