The Release of Quinine Sulfate from Polylactic Acid/Chitosan/Quinine Sulfate Composite Materials

Abstract

The polylactic acid/chitosan composite, recently used as a drug carrier to regulate the drug release, is aimed to increase drug effectiveness and decrease drug dosage. Polylactic acid/chitosan composite materials carrying 10-50% quinine sulfate were prepared using the water/oil water method to study the release of quinine sulfate. The effects of quinine sulfate content, pH and kinetics of quinine sulphate release were investigated. The results show that the higher the quinine sulfate content the polyacid/chitosan composite materials had, the slower the rate of quinine sulfate release was. The polylactic acid/chitosan composite materials carrying 50% quinine sulfate showed the slowest rate of quinine sulfate release. In pH = 7.4, the release rate of quinine sulfate was greater than in pH = 2.0. The process of releasing quinine sulfate from polylactic acid/chitosan/quinine sulfate composite materials follows the Korsmeyer-Peppas kinetics model and diffuses following the Fick law.

Keywords

Release, composite materials, polylactic acid, chitosan, quinin sulfate.

References

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