The Effects of Zoledronate on the Structure, Dissolution and Bioactivity of the Bioglass Composite: An Investigation by MAS-NMR and ICP-OES Methods

the structure and the dissolution of BG-0.1Z composite

Abstract

Abstract: Composite of bioglass (BG) with 0.1 wt.% of zoledronate (Z) has been elaborated for medical applications as reported in a previous study [1]. The synthetic material has been proven to be bioactive. This study used two physical-chemical methods: MAS-NMR (Magic angle spinning – nuclear magnetic resonance) and ICP-OES (Inductively coupled plasma – optical emission spectrometry) to clarify the effect of zoledronate on the structure, dissolution and bioactivity of BG. The obtained results show that the use of 0.1 wt.% of zoledronate modified the structural network, slowed down the dissolution and stimulated the bioactivity of bioglass.

Keywords: Bioglass, zoledronate, composite, lyophilization, in vitro, bioactivity.

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