the structure and the dissolution of BG-0.1Z composite
Bui Xuan Vuong

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Abstract

Zoledronate (Z) - one type of bisphosphonate has associated with bioglass (BG) to elaborate composite material for medical applications. The mixture of glass particles in zoledronate solution was stirred, frozen and lyophilized to obtain composite material containing 0.1 wt% of zoledronate (noted composite BG-0.1Z). The NMR analysis highlighted the effects of zoledronate introduced on the structure of bioglass. The ICP-OES method was used to evaluate the dissolution of synthetic composite in a simulated body fluid (SBF). Obtained results show that the introduction of 0.1 wt% of zoledronate affecting to the dissolution and bioactivity of bioglass.