Chemical Composition of Euphorbia Hirta L. collected in Dan Phuong, Hanoi
Main Article Content
Abstract
During the screening for biological active compounds from the medicinal plant, a species of Euphorbia hirta L. collected from Dan Phuong-Hanoi was utilized for its phytochemical study. From the n-butanol extract, eight compounds, including nonacosan-1-ol (1); β-sitosterol (2); β-sitosterol glucoside (3); quercetin (4); nicotiflorin (5); rutin (6); afzelin (7) and quercitrin (8) have been isolated. Their structures were determined by analysis of IR, MS and NMR (1D and 2D) spectroscopy as well as by comparison with published data.
Keywords:
Euphorbia hirta L., flavonoids, triterpene glycoside, sterol.
References
[1] R. Babujanarthanam, P. Kavitha, Rajalakshmi. Antihyperglycaemic and Antioxidant Role of Quercitrin, a Bio-Flavonoid, in Streptozotocin-Induced Diabetic Wistar Rat Tissues, Journal of Pharmacy Research, Vol. 4, No. 10, 2011, pp. 3833-3837.
[2] O. E. Ekpo, E. Pretorius, Asthma, Euphorbia Hiria and its Anti-inflammatory Properties, Vol. 103, No. 5, 2007, pp. 202-203.
[3] D. T. Loi, Vietnamese Medicinal Plants and Herbs, Medical Publishing House, 2001.
[4] M. Ernst, O. M. Grace, S. Lagoudakis C. H. N. Nilsson, H. T. Simonsen, N. Ronsted, Global Medicinal uses of Euphorbia L. (Euphorbiaceae), J. Ethnopharmacol, Vol. 176, 2015, pp. 90-101.
[5] National Institute of Medicinal Materials, Medicinal Plants and Animals in Medicine in Vietnam, Medical Publishing House, Vol. 1, 2002, pp. 503-505.
[6] Dictionary of Vietnamese Medicinal Plants, Medical Publishing House, 2012.
[7] L. Huang, S. Chen, M. Yang, Euphorbia Hirta (Feiyangcao): A Review on its Ethnopharmacology, Phytochemistry and Pharmacology, Med, Plants Res, Vol. 6, No. 39, 2012, pp. 5176-5185.
[8] S. Kumar, Rashmi, D. Kumar, Evaluation of Antidiabetic Activity of Euphorbia Hirta Linn in Streptozotocin Induced Diabetic Mice, India Journal of Natural Products and Resources, Vol. 1, No. 2, 2010, pp. 200-203.
[9] Y. P. Kwan, T. Saito, D. Ibrahim, F. M. S. Al-Hassan, C. E. Oon, Y. Chen, S. L. Jothy, J. R. Kanwar, S. Sasidharan, Evaluation of the Cytotoxicity, Cell-cycle Arrest, and Apoptotic Induction by Euphorbia Hirta in MCF-7 Breast Cancer Cells, Pharm Biol, Vol. 54, No. 7, 2015, pp. 1223-1236.
[10] M. Ogunlesi, W. Okiei, E. Ofor, A. E. Osibote, Analysis of the Essential Oil from the Dried Leaves of Euphorbia Hirta Linn (Euphorbiaceae), a Potential Medication for Asthma, African Journal of Biotechnology, 2009.
[11] S. Ahmad, M. Ali, S. H. Ansari, F. Ahmed, Der Pharma Chemica, Vol. 3, No. 2, 2011, pp. 505-511.
[12] V. S. P. Chaturvedula, I. Prakash, Isolation of Stigmasterol and b-sitosterol from the Dicholormethane Extract of Rubus Suavissimus, International Current Pharmaceutical Journal, Vol. 1, No. 9, 2012, pp. 239-242.
[13] D. N. Olennikov, L. M. Tankhaeva, V. V. Partilkhaev, A. V. Rokhin, Chemical Constituents of Caragana Bungei Shoots, Brazilian Journal of Pharmacognosy, Vol. 22, No. 3, 2012, pp. 490-496.
[14] Z. Guvenalp, N. Kilic, C. Kazaz, Y. Kaya, O. Demirezer, Chemical Constituents of Galium Tortumense, Turk J. Chem, Vol. 30, 2006, pp. 515-523.
[15] T. T. Trinh, V. S. Tran, T. H. A. Nguyen, Study on the Chemical Constituents of Fissistigma Pallens, Vietnam J. Chem., Vol. 44, No. 4, 2006, pp. 412-417.
[16] S. Bose, S. Maji, P. Chakraborty, Quercitrin from Ixora Coccinea Leaves and its Antioxidant Activity, Journal of Pharma Sci Tech, Vol. 2, No. 2, 2013, pp. 72-74.
[2] O. E. Ekpo, E. Pretorius, Asthma, Euphorbia Hiria and its Anti-inflammatory Properties, Vol. 103, No. 5, 2007, pp. 202-203.
[3] D. T. Loi, Vietnamese Medicinal Plants and Herbs, Medical Publishing House, 2001.
[4] M. Ernst, O. M. Grace, S. Lagoudakis C. H. N. Nilsson, H. T. Simonsen, N. Ronsted, Global Medicinal uses of Euphorbia L. (Euphorbiaceae), J. Ethnopharmacol, Vol. 176, 2015, pp. 90-101.
[5] National Institute of Medicinal Materials, Medicinal Plants and Animals in Medicine in Vietnam, Medical Publishing House, Vol. 1, 2002, pp. 503-505.
[6] Dictionary of Vietnamese Medicinal Plants, Medical Publishing House, 2012.
[7] L. Huang, S. Chen, M. Yang, Euphorbia Hirta (Feiyangcao): A Review on its Ethnopharmacology, Phytochemistry and Pharmacology, Med, Plants Res, Vol. 6, No. 39, 2012, pp. 5176-5185.
[8] S. Kumar, Rashmi, D. Kumar, Evaluation of Antidiabetic Activity of Euphorbia Hirta Linn in Streptozotocin Induced Diabetic Mice, India Journal of Natural Products and Resources, Vol. 1, No. 2, 2010, pp. 200-203.
[9] Y. P. Kwan, T. Saito, D. Ibrahim, F. M. S. Al-Hassan, C. E. Oon, Y. Chen, S. L. Jothy, J. R. Kanwar, S. Sasidharan, Evaluation of the Cytotoxicity, Cell-cycle Arrest, and Apoptotic Induction by Euphorbia Hirta in MCF-7 Breast Cancer Cells, Pharm Biol, Vol. 54, No. 7, 2015, pp. 1223-1236.
[10] M. Ogunlesi, W. Okiei, E. Ofor, A. E. Osibote, Analysis of the Essential Oil from the Dried Leaves of Euphorbia Hirta Linn (Euphorbiaceae), a Potential Medication for Asthma, African Journal of Biotechnology, 2009.
[11] S. Ahmad, M. Ali, S. H. Ansari, F. Ahmed, Der Pharma Chemica, Vol. 3, No. 2, 2011, pp. 505-511.
[12] V. S. P. Chaturvedula, I. Prakash, Isolation of Stigmasterol and b-sitosterol from the Dicholormethane Extract of Rubus Suavissimus, International Current Pharmaceutical Journal, Vol. 1, No. 9, 2012, pp. 239-242.
[13] D. N. Olennikov, L. M. Tankhaeva, V. V. Partilkhaev, A. V. Rokhin, Chemical Constituents of Caragana Bungei Shoots, Brazilian Journal of Pharmacognosy, Vol. 22, No. 3, 2012, pp. 490-496.
[14] Z. Guvenalp, N. Kilic, C. Kazaz, Y. Kaya, O. Demirezer, Chemical Constituents of Galium Tortumense, Turk J. Chem, Vol. 30, 2006, pp. 515-523.
[15] T. T. Trinh, V. S. Tran, T. H. A. Nguyen, Study on the Chemical Constituents of Fissistigma Pallens, Vietnam J. Chem., Vol. 44, No. 4, 2006, pp. 412-417.
[16] S. Bose, S. Maji, P. Chakraborty, Quercitrin from Ixora Coccinea Leaves and its Antioxidant Activity, Journal of Pharma Sci Tech, Vol. 2, No. 2, 2013, pp. 72-74.