Cytotoxic and Antimicrobial Secondary Metabolites from Penicillium hetheringtonii IMBC-NMTP04

Tran Hong Quang, Le Ngoc Anh, Ninh Thi Ngoc, Le Thi Vien, Do Hoang Anh, Nguyen Thi Huong, Tran Thi Hong Hanh, Nguyen Xuan Cuong, Nguyen Thi Thanh Ngan, Nguyen Quang Trung, Nguyen Hoai Nam

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Published Sep 7, 2023
DOI: https://doi.org/10.25073/2588-1140/vnunst.5439

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QUANG, Tran Hong et al. Cytotoxic and Antimicrobial Secondary Metabolites from Penicillium hetheringtonii IMBC-NMTP04. VNU Journal of Science: Natural Sciences and Technology, [S.l.], v. 39, n. 3, sep. 2023. ISSN 2588-1140. Available at: <https://js.vnu.edu.vn/NST/article/view/5439>. Date accessed: 21 nov. 2024. doi: https://doi.org/10.25073/2588-1140/vnunst.5439.
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Issue
Vol 39 No 3
Section
Original Articles

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Abstract

Chemical investigation of the sesame-associated fungal strain Penicillium hetheringtonii IMBC-NMTP04 resulted in isolation of five compounds, penicitrinone A (1), dihydrocitrinin (2), janthinone (3), coniochaetone B (4), and 9-oxo-10(E),12(E)-octadecadienoic acid (5). Their chemical structures were elucidated by spectroscopic methods, including 1D and 2D NMR and mass spectra in comparison with the literature data. Compound 1 showed modest cytotoxicity toward LNCaP, HepG2, MCF-7, KB, SK-Mel-2, and HL-60 human cancer cell lines, with IC50 values ranging from 60.1 to 84.2 mM while 5 was cytotoxic toward only HL-60 cell line (IC50 = 71.6 mM). All the compounds significantly inhibited E. faecalis, S. enterica, and C. albicans growth, with MIC values ranging from 12.5 to 50.0 mM. Compounds 2, 4, and 5 suppressed the growth of B. cereus, while both 1 and 2 showed antimicrobial effect against E. coli, with the same MIC value of 200 mM. This is the first time to report the chemical constituents of Penicillium hetheringtonii and the antimicrobial effect of 2–4.

Keywords: Penicillium hetheringtonii, secondary metabolites, cytotoxic; antimicrobial.

References

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