Chemical Constituents of Caesalpinia bonduc
Main Article Content
Abstract
This phytochemical investigation of Caesalpinia bonduc reported eight known compounds, namely threo-2,3-bis(4-hydroxy-3-methoxyphenyl)-3-methoxy-propanol (1), evofolin-B (2), trans-Linalool-3,6-oxide-β-D-glucopyranoside (3), 1-(2-methylbutyryl)phloroglucinol-glucopyranoside (4), 1-(3 methylbutyryl)phloroglucinol-glucopyranoside (5), (+)-isolariciresinol (6), protocatechuic acid (7), methyl gallate (8). The structures of these compounds were identified by 1D- and 2D- nuclear magnetic resonance (NMR) spectroscopy and mass spectrometry (MS) and by comparison with those reported in the literature. Compound 2 exhibited significant cytotoxic effects against the HepG2 cell line with an IC50 value of 48.37±3.18 µM.
Keywords:
Caesalpinia bonduc, cytotoxic, HepG2 inhibitory.
References
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https://doi.org/10.1016/j.fct.2009.04.040.
[9] J. J. Hsiao, H. C. Chiang, Lignans from the Wood of Aralia bipinnata, Phytochemistry, Vol. 39,
No. 4, 1995, pp. 899-902, https://doi.org/10.1016/0031-9422(95)00072-F.
[10] T. S. Wu, J. H. Yeh, P. L. Wu, The Heartwood Constituents of Tetradium glabrifolium, Phytochemistry, Vol. 40, No. 1, 1995, pp. 121-124, https://doi.org/10.1016/0031-9422(95)00248-6.
[11] Y. L. Li, J. G. Zhang, P. Yu, et al., New Monoterpenes, Diterpenes, and Lignans from Abies recurvata, Planta Medica, Vol. 78, No. 14, 2012, pp. 1574-1578, https://doi.org/10.1055/s-0032-1315111.
[12] G. Bohr, C. Gerhäuser, J. Knauft, et al., Anti-inflammatory Acylphloroglucinol Derivatives from Hops (Humulus lupulus), Journal of Natural products, Vol. 68, No. 10, 2005, pp. 1545-1548, https://doi.org/10.1021/np050164z.
[13] N. Jung, S. Bräse, Diaryl Ether and Diaryl Thioether Syntheses on Solid Supports via Copper (I)-Mediated Coupling, Journal of Combinatorial Chemistry, Vol. 11, No. 1, 2009, pp. 47-71, https://doi.org/10.1021/cc800032q.
[14] A. Jutiviboonsuk, H. Zhang, G. T. Tan, et al., Bioactive Constituents from Roots of Bursera tonkinensis, Phytochemistry, Vol. 66, No. 23, 2005, pp. 2745-2751, https://doi.org/10.1016/j.phytochem.2005.09.025.
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