Saponins from the Leaves of Eclipta prostrata
Main Article Content
Abstract
Eclipta prostrata (L.) is a traditional herbal medicine belonging to the Eclipta genus in the Asteraceae family. This plant is widely distributed in tropical and subtropical regions such as South America and Asia. According to the traditional medicine of some Asian countries
(China, India, Thailand), E. prostrata is used to treat hepatic and renal diseases, diabetes, skin diseases, respiratory disorders, cool blood, and stanch bleeding. Besides, it also shows antioxidant, anti-inflammatory, antibacterial, and antimicrobial activities. In Vietnam, the plant grows naturally in moist soil and is distributed from mountainous areas to plains. It is used to treat coughs and burns, respiratory infections, and boils. In this research, four saponins including eclalbasaponin I-II and eclalbasaponin IV-V were isolated from the methanol extract of Eclipta prostrata using various modern chromatography methods such as TLC, CC, and HPLC. Their chemical structures were identified by analysis of 1D, 2D-NMR, and ESI-MS spectra data and by comparison of the spectral data in the literature. Eclalbasaponin IV and V were first reported from Eclipta prostrata cultivated in Vietnam.
References
[2] I. M. Chung, G. Rajakumar, J. H. Lee, S. H. Kim, M. Thiruvengadam, Ethnopharmacological Uses, Phytochemistry, Biological Activities, and Biotechnological Applications of Eclipta prostrata, Applied Microbiology Biotechnology, Vol. 101, 2017, pp. 5247-5257, https://doi.org/10.1007/s00253-017-8363-9.
[3] Park, J.H., H. Lee, W.M. Yang, The Effects of Eclipta prostrata L. (Ecliptae Herba) on Periodontitis Rats. The Journal of Korean Medicine, Vol. 39, No. 1, 2018, pp. 63-74, https://doi.org/10.13048/jkm.18007.
[4] Li Feng, Yuan-Yuan Zhai, Jia Xu, Wei-Feng Yao, Yu-Dan Cao, Fang-Fang Cheng, Bei-Hua Bao, Li Zhang, A Review on Traditional Uses, Phytochemistry and Pharmacology of Eclipta prostrata (L.) L. Journal of Ethnopharmacology, Vol. 245, 2019, https://doi.org/10.1016/j.jep.2019.112109.
[5] Tewtrakul, S., Subhadhirasakul, S., Tansakul, P., Cheenpracha, S., Karalai, C., Antiinflammatory Constituents from Eclipta prostrata Using RAW264.7 Macrophage Cells. Phytotherapy Research, , Vol. 25, No. 9, 2011, pp. 1313-1316, https://doi.org/10.1002/ptr.338.
[6] Kim, D. I., Lee, S. H., Choi, J. H., Lillehoj, H. S., Yu, M. H., Lee, G. S., The Butanol Fraction of Eclipta prostrata (Linn) Effectively Reduces Serum Lipid Levels and Improves Antioxidant Activities in CD Rats. Nutrition Research, Vol.28, No. 8, 2008, pp. 550-554, https://doi.org/10.1016/j.nutres.2008.05.003.
[7] Rahman, M.S., M.A. Rashid, Antimicrobial Activity and Cytotoxicity of Eclipta prostrata. Advances in Traditional Medicine, Vol. 8, No. 1, 2008, pp. 47-52, https://doi.org/10.3742/OPEM.2008.8.1.047.
[8] Acid and Eclalbasaponin II isolated from Eclipta Prostrata L. (Asteraceae family). Can Tho University Journal of Science, No. 11b, 2009, pp. 278-283 (in Vietnamese).
[9] Do Huy Bich, Đ.Q.C., Bui Xuan Chuong, Nguyen Thuong Dong, Do Trung Dam, Pham Van Hien, Vu Ngọc Lo, Pham Duy Mai, Pham Kim Man, Doan Thi Nhu, Nguyen Tap, Tran Toan, Medicinal Plants and Animals in Vietnam. Science and Technology Publishing House, Vol. 2, 2006 (in Vietnamese).
[10] Huynh Kim Dieu, Le Thi Loan Em, Assessment Pure Characteristic and Antibacteria of Eclipta prostrata and Phyllanthus niruri in Cuu Long River Delta. Can Tho University Journal of Science, No. 19a, 2011, pp. 149-155 (in Vietnamese).
[11] Yahara, S., N. Ding, T. Nohara, Oleanane Glycosides from Eclipta alba. Chemical Pharmaceutical Bulletin, Vol. 42, No. 6, 1994, pp. 1336-1338, https://doi.org/10.1248/cpb.42.1336.
[12] Phan Minh Giang, Nguyen Thi Thoi, Nguyen Van Tai, Phan Tong Son, Study on chemical constituents of Eclipta prostrata L., Asteraceae in Vietnam. Vietnam Journal of Chemistry, Vol. 53 , No. 1, 2015, pp. 56-61 (in Vietnamese). https://doi.org/10.15625/0866-7144.2015-0088.