Flavonoids from the Rhizomes of Kaempferia Parviflora Wall. Ex Baker
Main Article Content
Abstract
Kaempferia parviflora Wall. ex Baker, Zingiberaeceae has been used in traditional medicine in Vietnam for the treatment of inflammation, abdominal pain, indigestion, menstrual cramps, fatigue. From the n-hexane fraction of the rhizomes of Kaempferia parviflora, six compounds were isolated and determined as 5-hydroxy-3,7-dimethoxyflavone (1), 5,7-dimethoxy chrysin (2), 5-hydroxy-7-methoxyflavone (3), 5-hydroxy-3,4',7-trimethoxyflavone (4), 4',5,7-trimethoxyflavone (5), and 3,4',5,7-tetramethoxyflavone (6). The structures of 1-6 were elucidated by extensive spectroscopic methods (MS, 1D, and 2D NMR)
Keywords:
Kaempferia parviflora, Zingiberaceae, flavonoid, black ginger
References
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2. Kaempferia [cited 2023 October 15]; Available from: https://powo.science.kew.org/results?f=accepted_names&page.size=120&q=Kaempferia.
3. A. Singh, N. Singh, S. Singh, R. P. Srivastava, L. Singh, P. C. Verma, H. P. Devkota, L. ur Rahman, K. B. Rajak, A. Singh, G. Saxena (2023), The industrially important genus Kaempferia: An ethnopharmacological review, Frontiers in Pharmacology, 14:1099523. https://doi.org/10.3389/fphar.2023.1099523.
4. Đ. T. Mai, T. P. Nguyen, T. C. Mai, Q. T. Pham, H. K. Tran, V. S. Dang, T. N. D. Nguyen, Chemical constituents of the rhizomes of Kaempferia parviflora, CTU Journal of Science, Vol. 57, No. 1, 2021, pp. 45-50. [In Vietnamese] DOI: 10.22144/ctu.jvn.2021.007.
5. D. Chen, H. Li, W. Li, S. Feng, D. Deng (2018), Kaempferia parviflora and its methoxyflavones: Chemistry and biological activities, Evidence-Based Complementary and Alternative Medicine, 2018, 4057456. https://doi.org/10.1155/2018/4057456.
6. S. Tewtrakul, S. Subhadhirasakul, S. Kummee, Anti-allergic activity of compounds from Kaempferia parviflora, Journal of ethnopharmacology, Vol. 116, No. 1, 2008, pp. 191-193. https://doi.org/10.1016/j.jep.2007.10.042.
7. S. Tewtrakul, S. Subhadhirasakul, C. Karalai, C. Ponglimanont, S. Cheenpracha, Anti-inflammatory effects of compounds from Kaempferia parviflora and Boesenbergia pandurata, Food Chemistry, Vol. 115, No. 2, 2009, pp. 534-538. https://doi.org/10.1016/j.foodchem.2008.12.057.
8. S. Tewtrakul, S. Subhadhirasakul, Effects of compounds from Kaempferia parviflora on nitric oxide, prostaglandin E2 and tumor necrosis factor-alpha productions in RAW264.7 macrophage cells, Journal of ethnopharmacology, Vol. 120, No. 1, 2008, pp. 81-84. https://doi.org/10.1016/j.jep.2008.07.033.
9. J. Wattanathorn, T. Tong-un, S. Muchimapura, P. Wannanon, B. Sripanidkulchai, W. Phachonpai, Anti-stress effects of Kaempferia parviflora in immobilization subjected rats, American Journal of Pharmacology and Toxicology, Vol. 8, No. 1, 2013, pp. 31-38. https://doi.org/10.3844/ajptsp.2013.31.38.
10. S. Kummee, S. Tewtrakul, S. Subhadhirasakul, Antimicrobial activity of the ethanol extract and compounds from the rhizomes of Kaempferia parviflora, Songklanakarin Journal of Science & Technology, Vol. 30, No. 4, 2008, pp. 463-466.
11. R. Banjerdpongchai, K. Suwannachot, V. Rattanapanone, B. Sripanidkulchai, Ethanolic rhizome extract from Kaempferia parviflora Wall. ex. Baker induces apoptosis in HL-60 cells, Asian Pacific Journal of Cancer Prevention, Vol. 9, No. 4, 2008, pp. 595-600.
12. V. Leardkamolkarn, S. Tiamyuyen, B. Sripanidkulchai, Pharmacological activity of Kaempferia parviflora extract against human bile duct cancer cell lines, Asian Pacific Journal of Cancer Prevention, Vol. 10, No. 4, 2009, pp. 695-698.
13. V. T. Nguyen, Vietnamese medicinal plants and commonly used remedies, Vol. III, Medical Publishing House, 2020, pp. 144-146. (In Vietnamese)
14. S. Saokaew, P. Wilairat, P. Raktanyakan, P. Dilokthornsakul, T. Dhippayom, C. Kongkaew, R. Sruamsiri, A. Chuthaputti, N. Chaiyakunapruk, Clinical effects of Krachaidum (Kaempferia parviflora): a systematic review, Journal of Evidence-Based Complementary & Alternative Medicine, Vol. 22, No. 3, 2017, pp. 413-428. https://doi.org/10.1177/2156587216669628
15. K. Toda, S. Hitoe, S. Takeda, H. Shimoda, Black ginger extract increases physical fitness performance and muscular endurance by improving inflammation and energy metabolism, Heliyon, Vol. 2, No. 5, 2016, e00115. https://doi.org/10.1016/j.heliyon.2016.e00115
16. C. Yenjai, K. Prasanphen, S. Daodee, V. Wongpanich, P. Kittakoop, Bioactive flavonoids from Kaempferia parviflora, Fitoterapia, Vol. 75, No. 1, 2004, pp. 89-92. https://doi.org/10.1016/j.fitote.2003.08.017.
17. S. Chaipech, T. Morikawa, K. Ninomiya, M. Yoshikawa, Y. Pongpiriyadacha, T. Hayakawa, O. Muraoka, Structures of two new phenolic glycosides, kaempferiaosides A and B, and hepatoprotective constituents from the rhizomes of Kaempferia parviflora, Chemical Pharmaceutical Bulletin, Vol. 60, No. 1, 2012, pp. 62-69. https://doi.org/10.1248/cpb.60.62
18. T. Azuma, Y.Tanaka, H. Kikuzaki, Phenolic glycosides from Kaempferia parviflora, Phytochemistry, Vol. 69, No. 15, 2008, 2743-2748.https://doi.org/10.1016/j.phytochem.2008.09.001