Chemical Constituents of Eupatorium clematideum Species in Vietnam
Main Article Content
Abstract
There are about 25 Eupatorium species that have been studied for their chemical constituents. Eupatorium clematideum (Wall. Ex DC.) Sch. Bip. (syn. Praxelis clematidea R.M. King & H. Rob.) in Vietnam has not been investigated for chemical metabolites from organic extracts, although the study of volatile terpenoids in the essential oils from different parts of the plant proved biological activities of the oil chemicals. A phytochemical study of the whole plant of E. clematideum in Vietnam led to the isolation of phytosterol, fatty acids, flavonoids, and a cyclohexanetriol. The identification of their structures was based on the analysis of MS and NMR spectroscopic data followed by data comparison with the literature values. The flavone (compounds 6 and 7) and flavonol (compound 5) are two types of flavonoids found in the
organic extracts of E. clematideum; their biological activities should orientate the preparation of flavonoid-enriched extracts with pharmacological potentials from E. clematideum.
Keywords:
Eupatorium clematideum, Praxelis clematidea, flavone, flavonol, cyclohexanetriol, NMR data.
References
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pp. 1621-1626, https://doi.org/10.1007/s11094-024-03057-6.
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[18] P. T. Phat, L. H. Ngoan, Isolation of three Polymethoxylated Flavones from Ageratum conyzoides L. growing in Can Tho City, Can Tho University Journal of Innovation and Sustainable Development, Vol. 4, 2016, pp. 13-19, https://doi.org/10.22144/ctu.jen.2016.038.
[19] S. A. Ayatollahi, A. Shojaii, F. K. M. Mohammadzadehd, M. I. Choudharye, Two Flavones from Salvia leriaefolia, Iranian Journal of Pharmaceutical Research, Vol. 8, No. 3, 2009, pp. 179-184, https://doi.org/10.22037/ijpr.2010.808.
[20] G. A. Zou, Z. H. Su, H. W. Zhang, Y. Wang, J. S. Yang, Z. M. Zou, Flavonoids from the Stems of Croton caudatus Geisel. var. tomentosus Hook, Molecules, Vol. 15, No. 3, 2010, pp. 1097-1102, https://doi.org/10.3390/molecules15031097.
[21] F. Labeda, M. Masullo, A. Cerullib, F. Benayachea, S. Benayachea, S. Piacenteb, Chemical Constituents of the Aerial Parts of Santolina chamaecyparissus and Evaluation of Their Antioxidant Activity, Natural Product Communication, Vol. 12, No. 10, 2017, pp. 1605-1608, https://doi.org/10.1177/1934578X1701201020.
[22] N. P. Hung, H. D. Thuan, N. T. Thao, V. Q. Trung, P. Q. Long, Some Flavonoids Isolated from Orthosiphon stamineus Benth. in Vietnam, Danang University Journal of Science and Technology, Vol. 5, No. 1, 2017, pp. 133-135, https://jst-ud.vn/jst-ud/article/view/3225 (in Vietnamese).
[23] J. Xia , M. Xu, H. Hu, Q. Zhang, D. Yu, M. Cai, X. Geng, H. Zhang, Y. Zhang, M. Guo, D. Lu, H. Xu, L. Li, X. Zhang,
Q. Wang, S. Liu, W. Zhang, 5,7,4'-Trimethoxyflavone Triggers Cancer Cell PD-L1 ubiquitin-proteasome Degradation and Facilitates Antitumor Immunity by Targeting HRD1, MedComm, Vol. 5, No. 7, 2024, pp. e611, https://doi.org/10.1002/mco2.611.
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[27] S. Pattara S., T. Patcharin, Vasorelaxant Effects of 5,7,4′-trimethoxyflavone from Kaepmferia parviflora in the Rat Aorta, International Journal of Pharmacology, Vol. 6, No. 4, 2010, pp. 419-424, https://doi.org/10.3923/ijp.2010.419.424.