Determination of Non-Steroidal Anti-Inflammatory Drugs (Nsaids) in Surface Water at Ho Chi Minh City

Abstract

Abstract: This study aims at setting up an analytical method for determination of 4 Non-Steroidal Anti-Inflammatory Drugs (NSAIDs) including ketoprofen, ibuprofen, diclofenac sodium and mefenamic acid in surface water. The method studied involved solid phase extraction (SPE) using Poly-Sery PSD (Poly styrene divinylbenzene) SPE catridge and analysis by high-performance liquid chromatography (HPLC) with DAD detector. The recoveries were found in the range of 82% - 98% with relative standard deviations (RSD) of less than 10% and method detection limits (MDL) were from 0.004 to 0.015µg/L. This method was used to determine the selected compounds in fifteen surface water samples collected in Ho Chi Minh City. The analysis results show that their residues currently do exist in surface water in the study area.

Keywords: NSAIDs, HPLC-DAD, surface water.