Nguyen Xuan Bach, Nguyen Thanh Hai, Nguyen Huong Ly, Nguyen Van Tuan

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Abstract: According to the WHO (World Health Organization), unipolar depressive disorders were ranked as the third leading cause of the Global Burden of Disease in 2004 and are expected to move into the first place by 2030. Methods: Research conducted on 65 patients at the National Institute of Mental Health to examine the use of drugs, their side effects, drug interactions and effectiveness of treatment in these patients. Results: The study results showed that Sertraline was the most widely used antidepressant (39.5%), followed by Mirtazapine (38.3%). Adverse events in the most common symptoms were resulted from cholinergics. There were 12 patients (18.5%) recorded experiencing adverse events on weight. The rate of remission HAM-D 17 scale scores after treatment was 66.2 ± 13.8%. Conclusions: New antidepressants were commonly used and had effects among the unipolar depressive patients in Vietnam. Clinicians should pay attention to such side effects as cholinergic adverse events and weight gain among patients.


Antidepressant, depression, side effects, drug use


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