Main Article Content
Platelet-rich plasma (PRP) is an autologous physiological product that has a platelet concentration above baseline. The PRP contains a high level of important growth factors and cytokines such as PDGF, EGF, VEGF, TGF-β,... which play important roles in healing and tissue regeneration. The PRP is currently used in various medical fields, including orthopedic, plastic surgery, dermatology, dentistry, musculoskeletal and obstetrics-gynecology. To date, the results from in vitro, in vivo studies to clinical trials have proved the effectiveness of PRP in the treating of many diseases. Altogether, PRP is considered to be a very promising futuristic therapy by dint of its simple and highly potential clinical application.
Keywords: Platelet-rich plasma, PRP, growth factors, applications of platelet-rich plasma.
 J. S. F. Moure, J. L. V. Eps, F. J. Cabrera, Z. Barbosa, G. M. D. Rosal, B. K. Weiner, et al., Platelet-rich Plasma: A Biomimetic Approach to Enhancement of Surgical Wound Healing, Journal of Surgical Research, Vol. 207, No., 2017, pp. 33-44, https://doi.org/10.1016/j.jss.2016.08.063.
 A. Zarbock, R. K. P. Grabowska, K. Ley, Platelet-neutrophil-interactions: Linking Hemostasis and Inflammation, Blood Reviews, Vol. 21, No. 2, 2007, pp. 99-111, https://doi.org/10.1016/j.blre.2006.06.001.
 R. E. Marx, Platelet-rich Plasma (PRP): what is PRP and what is not PRP?, Implant Dentistry,
Vol. 10, No. 4, 2001, pp. 225-228, https://doi.org/10.1097/00008505-200110000-00002.
 R. Alves, R. Grimalt, A Review of Platelet-Rich Plasma: History, Biology, Mechanism of Action, and Classification, Skin Appendage Disord, Vol. 4, No. 1, 2018, pp. 18-24, https://doi.org/10.1159/000477353.
 P. A. Everts, J. T. Knape, G. Weibrich, J. P. Schonberger, J. Hoffmann, E. P. Overdevestet al., Platelet-rich Plasma and Platelet Gel: A Review, The Journal of ExtraCorporeal Technology, Vol. 38, No. 2, 2006, pp. 174-187.
 A. Mishra, J. W. Jr, A. Vieira, Treatment of Tendon and Muscle Using Platelet-rich Plasma, Clinics in Sports Medicine, Vol. 28, No. 1, 2009, pp. 113-125, https://doi.org/10.1016/j.csm.2008.08.007.
 R. Dhurat, M. Sukesh, Principles and Methods of Preparation of Platelet-rich Plasma: A Review and Author's Perspective, Journal of Cutaneous Aesthetic Surgery, Vol. 7, No. 4, 2014, pp. 189-197, https://doi.org/10.4103/0974-2077.150734.
 B. L. Eppley, W. S. Pietrzak, M. Blanton, Platelet-rich Plasma: A Review of Biology and Applications in Plastic Surgery, Plastic and Reconstructive Surgery, Vol. 118, No. 6, 2006, pp. 147e-159e, https://doi.org/10.1097/01.prs.0000239606.92676.cf.
 K. Mautner, G. Malanga, R. Colberg, Optimization of Ingredients, Procedures and Rehabilitation for Platelet-rich Plasma Injections for Chronic Tendinopathy, Pain Management, Vol. 1, No. 6, 2011, pp. 523-532, https://doi.org/10.2217/pmt.11.56.
 C. Kia, J. Baldino, R. Bell, A. Ramji, C. Uyeki, A. Mazzocca, Platelet-rich Plasma: Review of Current Literature on its Use for Tendon and Ligament Pathology, Current Reviews in Musculoskeletal Medicine, Vol. 11, No. 4, 2018, pp. 566-572, https://doi.org/10.1007/s12178-018-9515-y.
 J. Alsousou, M. Thompson, P. Hulley, A. Noble, K. Willett, The Biology of Platelet-rich Plasma and its Application in Trauma and Orthopaedic Surgery: A Review of The Literature, The Journal of Bone and Joint Surgery British volume, Vol. 91, No. 8, 2009, pp. 987-996, https://doi.org/10.1302/0301-620X.91B8.22546.
 W. J. Berghoff, W. S. Pietrzak, R. D. Rhodes, Platelet-rich Plasma Application During Closure Following Total Knee Arthroplasty, Orthopedics, Vol. 29, No. 7, 2006, pp. 590-598, https://doi.org/10.3928/01477447-20060701-11.
 D. R. Knighton, K. F. Ciresi, V. D. Fiegel, L. L. Austin, E. L. Butler, Classification and Treatment of Chronic Nonhealing Wounds. Successful Treatment with Autologous Platelet-derived Wound Healing Factors (PDWHF), Annals of Surgery, Vol. 204, No. 3, 1986, pp. 322-330, https://doi.org/10.1097/00000658-198609000-00011.
 N. N. Tuan, N. T. Dung, Studying the Effects of Platelet-rich Plasma and Adipose Tissue-derived Stem cells on Chronic Wound Treatment, Journal of Disaster Medicine and Burn Injuries, Vol. 5, 2018 (in Vietnamese).
 D. M. Dohan Ehrenfest, T. Bielecki, A. Mishra, P. Borzini, F. Inchingolo, G. Sammartino et al., in Search of A Consensus Terminology in The Field of Platelet Concentrates for Surgical Use: Platelet-rich Plasma (PRP), Platelet-rich Fibrin (PRF), Fibrin Gel Polymerization and Leukocytes, Current Pharmaceutical Biotechnology, Vol. 13, No. 7, 2012, pp. 1131-1137, https://doi.org/10.2174/138920112800624328.
 D. H. Whitman, R. L. Berry, D. M. Green, Platelet Gel: An Autologous Alternative to Fibrin Glue with Applications in Oral and Maxillofacial Surgery, Journal of Oral Maxillofacial Surgery, Vol. 55, No. 11, 1997, pp. 1294-1299, https://doi.org/10.1016/s0278-2391(97)90187-7.
 P. A. Mooar, M. J. Gardner, P. R. Klepchick, The Efficacy of Autologous Platelet Gel in Total Knee Arthroplasty: An Analysis of Range of Motion, Hemoblobin, and Narcotic Requirements, In: 67th Annual Meeting. American Academy of Orthopaedic Surgeons, 2000.
 T. M. Bielecki, T. S. Gazdzik, J. Arendt, T. Szczepanski, W. Krol, T. Wielkoszynski, Antibacterial Effect of Autologous Platelet Gel Enriched with Growth Factors and Other Active Substances: An in Vitro Study, The Journal of Bone and Joint Surgery British volume, Vol. 89, No. 3, 2007, pp. 417-420, https://doi.org/10.1302/0301-620X.89B3.18491.
 D. J. Moojen, P. A. Everts, R. M. Schure, E. P. Overdevest, A. V. Zundert, J. T. Knape et al., Antimicrobial Activity of Platelet-leukocyte Gel Against Staphylococcus Aureus, Journal of Orthopaedic Research, Vol. 26, No. 3, 2008, pp. 404-410, https://doi.org/10.1002/jor.20519.
 D. M. D. Ehrenfest, L. Rasmusson, T. Albrektsson, Classification of Platelet Concentrates: from Pure Platelet-rich Plasma (P-PRP) to Leucocyte- and Platelet-rich Fibrin (L-PRF), Trends in Biotechnology, Vol. 27, No. 3, 2009, pp. 158-167, https://doi.org/10.1016/j.tibtech.2008.11.009.
 R. E. Marx, E. R. Carlson, R. M. Eichstaedt, S. R. Schimmele, J. E. Strauss, K. R. Georgeff, Platelet-rich Plasma: Growth Factor Enhancement for Bone Grafts, Oral Surgery Oral Medicine Oral Pathology Oral Radiology, Vol. 85, No. 6, 1998, pp. 638-646, https://doi.org/10.1016/s1079-2104(98)90029-4.
 R. Alissa, M. Esposito, K. Horner, R. Oliver, The Influence of Platelet-rich Plasma on The Healing of Extraction Sockets: An Explorative Randomised Clinical Trial, European Journal of Oral Implantology, Vol. 3, No. 2, 2010, pp. 121-134.
 R. C. Mariano, W. M. D. Melo, C. C. Avelino, Comparative Radiographic Evaluation of Alveolar Bone Healing Associated with Autologous Platelet-rich Plasma After Impacted Mandibular Third Molar Surgery, Journal of Oral and Maxillofacial Surgery, Vol. 70, No. 1, 2012, pp. 19-24, https://doi.org/10.1016/j.joms.2011.03.028.
 C. Bacci, M. Maglione, L. Favero, A. Perini, R. D. Lenarda, M. Berengo et al., Management of Dental Extraction in Patients Undergoing Anticoagulant Treatment. Results From A Large, Multicentre, Prospective, Case-control Study, Journal of Thrombosis and Haemostasis, Vol. 104, No. 5, 2010, pp. 972-975, https://doi.org/10.1160/TH10-02-0139.
 E. Anitua, M. Sanchez, A. T. Nurden, M. Zalduendo, M. D. L. Fuente, J. Azofra et al., Reciprocal Actions of Platelet-secreted TGF-beta1 on The Production of VEGF and HGF by Human Tendon Cells, Plastic and Reconstructive Surgery, Vol. 119, No. 3, 2007, pp. 950-959, https://doi.org/10.1097/01.prs.0000255543.43695.1d.
 B. O'Connell, N. M. Wragg, S. L. Wilson, The Use of PRP Injections in The Management of Knee Osteoarthritis, Cell and Tissue Research, Vol. 376, No. 2, 2019, pp. 143-152, https://doi.org/10.1007/s00441-019-02996-x.
 M. A. S. Mendia, J. F. V. Cavazos, H. G. M. Rodriguez, Platelet-rich Plasma in Knee Osteoarthritis Treatment, Cirugia y Cirujanos, Vol. 83, No. 4, 2015, pp. 352-358, https://doi.org/10.1016/j.circir.2014.06.001.
 H. H. E. Hadmed, R. F. Castillo, Cosmeceuticals: Peptides, Proteins, and Growth Factors, Journal of Cosmetic Dermatology, Vol. 15, No. 4, 2016, pp. 514-519, https://doi.org/10.1111/jocd.12229.
 D. H. Kim, Y. J. Je, C. D. Kim, Y. H. Lee, Y. J. Seo, J. H. Lee et al., Can Platelet-rich Plasma Be Used for Skin Rejuvenation? Evaluation of Effects of Platelet-rich Plasma on Human Dermal Fibroblast, Annals of Dermatology, Vol. 23, No. 4, 2011, pp. 424-431, https://doi.org/10.5021/ad.2011.23.4.424.
 N. Cameli, M. Mariano, I. Cordone, E. Abril, S. Masi, M. L. Foddai, Autologous Pure Platelet-Rich Plasma Dermal Injections for Facial Skin Rejuvenation: Clinical, Instrumental, and Flow Cytometry Assessment, Dermatologic Surgery, Vol. 43, No. 6, 2017, pp. 826-835, https://doi.org/10.1097/DSS.0000000000001083.
 O. K. Abuaf, H. Yildiz, H. Baloglu, M. E. Bilgili, H. A. Simsek, B. Dogan, Histologic Evidence of New Collagen Formulation Using Platelet Rich Plasma in Skin Rejuvenation: A Prospective Controlled Clinical Study, Annals of Dermatology, Vol. 28, No. 6, 2016, pp. 718-724, https://doi.org/10.5021/ad.2016.28.6.718.
 N. Y. Elnehrawy, Z. A. Ibrahim, A. M. Eltoukhy, H. M. Nagy, Assessment of the Efficacy and Safety of Single Platelet-rich Plasma Injection on Different Types and Grades of Facial Wrinkles, Journal of Cosmetic Dermatology, Vol. 16, No. 1, 2017, pp. 103-111, https://doi.org/10.1111/jocd.12258.
 B. Hersant, M. S. Mezi, J. Niddam, S. L. Padula, W. Noel, K. Ezzedine et al., Efficacy of Autologous Platelet-rich Plasma Combined with Hyaluronic Acid on Skin Facial Rejuvenation: A Prospective Study, Journal of the American Academy of Dermatology, Vol. 77, No. 3, 2017, pp. 584-586, https://doi.org/10.1016/j.jaad.2017.05.022.
 Z. A. Ibrahim, R. A. E. Tatawy, M. A. E. Samongy, D. A. Ali, Comparison Between The Efficacy and Safety of Platelet-rich Plasma vs. Microdermabrasion in the Treatment of Striae Distensae: Clinical and Histopathological Study, Journal of Cosmetic Dermatology, Vol. 14, No. 4, 2015, pp. 336-346, https://doi.org/10.1111/jocd.12160.
 A. Tuknayat, G. P. Thami, M. Bhalla, J. K. Sandhu, Autologous Intralesional Platelet-rich Plasma Improves Melasma, Dermatologic Therapy, Vol. 34, No. 2, 2021, pp. e14881, https://doi.org/10.1111/dth.14881.
 V. Cervelli, F. Nicoli, D. Spallone, S. Verardi, R. Sorge, M. Nicoli et al., Treatment of Traumatic Scars Using Fat Grafts Mixed with Platelet-rich Plasma, and Resurfacing of Skin with The 1540 nm Nonablative Laser, Clinical and Experimental Dermatology, Vol. 37, No. 1, 2012, pp. 55-61, https://doi.org/10.1111/j.13652230.2011.04199.x.
 A. C. Nita, O. A. Orzan, M. Filipescu, D. Jianu, Fat Graft, Laser CO(2) and Platelet-rich Plasma Synergy in Scars Treatment, Journal of Medicine and Life, Vol. 6, No. 4, 2013, pp. 430-433.
 R. James, R. Chetry, V. Subramanian, A. Ashtekar, N. Srikruthi, S. Ramachandran et al., Efficacy of Activated 3X Platelet-Rich Plasma in the Treatment of Androgenic Alopecia, Journal of Stem Cells, Vol. 11, No. 4, 2016, pp. 191-199.
 R. Alves, R. Grimalt, Randomized Placebo-Controlled, Double-Blind, Half-Head Study to Assess the Efficacy of Platelet-rich Plasma on the Treatment of Androgenetic Alopecia, Dermatologic Surgery, Vol. 42, No. 4, 2016, pp. 491-497, https://doi.org/10.1097/DSS.0000000000000665.
 C. E. Finch, The Menopause and Aging, A Comparative Perspective, The Journal of Steroid Biochemistry and Molecular Biology, Vol. 142, No., 2014, pp. 132-141, https://doi.org/10.1016/j.jsbmb.2013.03.010.
 Y. Chang, J. Li, Y. Chen, L. Wei, X. Yang, Y. Shi et al., Autologous Platelet-rich Plasma Promotes Endometrial Growth and Improves Pregnancy Outcome During In Vitro Fertilization, International Journal of Clinical and Experimental Medicine, Vol. 8, No. 1, 2015, pp. 1286-1290.
 S. Zadehmodarres, S. Salehpour, N. Saharkhiz, L. Nazari, Treatment of Thin Endometrium with Autologous Platelet-rich Plasma: A Pilot Study, JBRA Assisted Reproduction, Vol. 21, No. 1, 2017, pp. 54-56, https://doi.org/10.5935/1518-0557.20170013.
 Y. Chang, J. Li, L. N. Wei, J. Pang, J. Chen, X. Liang, Autologous Platelet-rich Plasma Infusion Improves Clinical Pregnancy Rate in Frozen Embryo Transfer Cycles for Women with Thin Endometrium, Medicine (Baltimore), Vol. 98, No. 3, 2019, https://doi.org/10.1097/MD.0000000000014062.
 S. R. Tandulwadkar, M. V. Naralkar, A. D. Surana, M. Selvakarthick, A. H. Kharat, Autologous Intrauterine Platelet-Rich Plasma Instillation for Suboptimal Endometrium in Frozen Embryo Transfer Cycles: A Pilot Study, Journal of Human Reproductive Sciences, Vol. 10, No. 3, 2017, pp. 208-212, https://doi.org/10.4103/jhrs.JHRS_28_17.
 A. Molina, J. Sanchez, W. Sanchez, V. Vielma, Platelet-rich Plasma As An Adjuvant in the Endometrial Preparation of Patients with Refractory Endometrium, JBRA Assisted Reproduction, Vol. 22, No. 1, 2018, pp. 42-48, https://doi.org/10.5935/1518-0557.20180009.
 K. Pantos, N. Nitsos, G. Kokkali, T. Vaxevanoglou, C. Markomichali, A. Pantou, Ovarian Rejuvenation and Folliculogenesis Reactivation in Peri-menopausal Women After Autologous Platelet-rich Plasma Treatment, in Proceedings of the 32nd Annual Meeting of ESHRE, Helsinki, Finland, 2016.
 K. Pantos, M. Simopoulou, A. Pantou, A. Rapani, P. Tsioulou, N. Nitsos, et al., A Case Series on Natural Conceptions Resulting in Ongoing Pregnancies in Menopausal and Prematurely Menopausal Women Following Platelet-rich Plasma Treatment, Cell Transplant, Vol. 28, No. 9-10, 2019, pp. 1333-1340, https://doi.org/10.1177/0963689719859539.
 J. Fanning, L. Murrain, R. Flora, T. Hutchings, J. M. Johnson, B. W. Fenton, Phase I/II Prospective Trial of Autologous Platelet Tissue Graft in Gynecologic Surgery, Journal of Minimally Invasive Gynecology, Vol. 14, No. 5, 2007, pp. 633-637, https://doi.org/10.1016/j.jmig.2007.05.014.
 X. Hua, Y. Zeng, R. Zhang, H. Wang, J. Diao, P. Zhang, Using Platelet-rich Plasma for the Treatment of Symptomatic Cervical Ectopy, International Journal of Gynaecology & Obstetrics, Vol. 119, No. 1, 2012, pp. 26-29, https://doi.org/10.1016/j.ijgo.2012.05.029.
 F. B. Willison, N. R. Pour, B. Mohamadi, N. Willison, M. Rock, I. W. Holten et al., Use of Platelet-rich Plasma for Vulvovaginal Autoimmune Conditions Like Lichen Sclerosus, Plastic and Reconstructive Surgery Global Open, Vol. 4, No. 11, 2016, pp. e1124, https://doi.org/10.1097/GOX.0000000000001124.
 M. Morelli, M. L. Rocca, R. Venturella, A. D. Cello, S. D. Negro, M. Condorelli et al., Adjuvant Use of Platelet Gel for Wound Breakdown Prevention in Advanced Vulvar Cancer Surgery: A Retrospective Study, International Journal of Gynecological Cancer, Vol. 23, No. 8, 2013, pp. 1490-1494, https://doi.org/10.1097/IGC.0b013e3182a50517.
 B. B. Adler, E. Hanzal, E. Pablik, H. Koelbl, K. Bodner, Management of Vesicovaginal Fistulas (VVFs) in Women Following Benign Gynaecologic Surgery: A Systematic Review and Meta-analysis, PLoS One, Vol. 12, No. 2, 2017, pp. e0171554, https://doi.org/10.1371/journal.pone.0171554.
 A. S. Plachokova, J. V. D. Dolder, P. J. Stoelinga, J. A. Jansen, The Bone Regenerative Effect of Platelet-rich Plasma in Combination with An Osteoconductive Material in Rat Cranial Defects, Clinical Oral Implants Research, Vol. 17, No. 3, 2006, pp. 305-311, https://doi.org/10.1111/j.1600-0501.2005.01208.x.
 A. S. Plachokova, J. V. D. Dolder, P. J. Stoelinga, J. A. Jansen, Early Effect of Platelet-rich Plasma on Bone Healing in Combination with An Osteoconductive Material in Rat Cranial Defects, Clinical Oral Implants Research, Vol. 18, No. 2, 2007, pp. 244-251, https://doi.org/10.1111/j.1600-0501.2006.01327.x.
 B. H. Choi, C. J. Im, J. Y. Huh, J. J. Suh, S. H. Lee, Effect of Platelet-rich Plasma on Bone Regeneration in Autogenous Bone Graft, International Journal of Oral Maxillofacial Surgery, Vol. 33, No. 1, 2004, pp. 56-59, https://doi.org/10.1054/ijom.2003.0466.
 B. L. Walters, D. A. Porter, S. J. Hobart, B. B. Bedford, D. E. Hogan, M. M. McHugh et al., Effect of Intraoperative Platelet-Rich Plasma Treatment on Postoperative Donor Site Knee Pain in Patellar Tendon Autograft Anterior Cruciate Ligament Reconstruction: A Double-Blind Randomized Controlled Trial, The American Journal of Sports Medicine, Vol. 46, No. 8, 2018, pp. 1827-1835, https://doi.org/10.1177/0363546518769295.
 G. E. Niazi, M. S. Hassan, D. M. Elfawy, Ultrasound-guided Injection of Platelet-rich Plasma (PRP) in Rotator Cuff Tendinopathy: Effect on Patients’ Symptoms and Supraspinatus Tendon Thickness, Egyptian Journal of Radiology and Nuclear Medicine, Vol. 51, No. 1, 2020, https://doi.org/ 10.1186/s43055-020-00221-2.
 L. D. Sante, C. Villani, V. Santilli, M. Valeo, E. Bologna, L. Imparato et al., Intra-articular Hyaluronic Acid vs Platelet-rich Plasma in the Treatment of Hip Osteoarthritis, Medical Ultrasonography, Vol. 18, No. 4, 2016,
pp. 463-468, https://doi.org/10.11152/mu-874.
 J. Wiltfang, K. A. Schlegel, S. S. Mosgau, E. Nkenke, R. Zimmermann, P. Kessler, Sinus Floor Augmentation with Beta-tricalciumphosphate (beta-TCP): Does Platelet-rich Plasma Promote its Osseous Integration and Degradation?, Clinical Oral Implants Research, Vol. 14, No. 2, 2003, pp. 213-218, https://doi.org/10.1034/j.16000501.2003.140212.x.
 J. H. Wang, X. Nirmala, Application of Tendon Stem/Progenitor Cells and Platelet-Rich Plasma to Treat Tendon Injuries, Operative Techniques in Orthopaedics, Vol. 26, No. 2, 2016, pp. 68-72, https://doi.org/10.1053/j.oto.2015.12.008.
 H. Toumi, T. M. Best, The Inflammatory Response: Friend or Enemy for Muscle Injury?, British Journal of Sports Medicine, Vol. 37, No. 4, 2003, pp. 284-286, https://doi.org/10.1136/bjsm.37.4.284.
 C. Smith, M. J. Kruger, R. M. Smith, K. H. Myburgh, The Inflammatory Response to Skeletal Muscle Injury: Illuminating Complexities, Sports Medicine, Vol. 38, No. 11, 2008, pp. 947-969, https://doi.org/10.2165/00007256-200838110-00005.