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Abstract: The estrogen-α (ER-α) receptor is an important target in breast cancer therapy. Alkaloids are a class of plant extracts that have the potential to inhibit ER-α receptors. In this study, we evaluated the ability of alkaloids to inhibit ER-α receptors by molecular docking method. Based on previous publications, we collected 52 alkaloid compounds. The results showed that there were 4 compounds with stronger inhibitory effects on ER-α receptors than positive controls, which are co-crystallized ligands with 4-hydroxytamoxifen. Conducting analysis according to Lipinski's 5-criteria rule and predicting pharmacokinetic-toxicological parameters, we obtained one compound with drug-like properties is Pityriacitrin B. Therefore, this compound has the potential to develop into drugs that inhibit ER-α receptors for breast cancer treatment.
Keywords: Breast cancer, ER-α, molecular docking, alkaloid, Pityriacitrin B.