Developing a Cardiovascular Drug-disease Interaction List and Evaluating the Effectiveness of its Management at Dong Da General Hospital

Abstract

Background: Drug–disease interactions (DDSIs) significantly affect treatment safety and effectiveness, particularly in cardiovascular patients with multimorbidity and polypharmacy. Objectives: To develop a list of cardiovascular drug–disease interactions and evaluate the effectiveness of drug information provision in DDSI management at Dong Da General Hospital. Methods: A cross-sectional study combined with a pre–post intervention design was conducted. A DDSI list was developed from multiple references and implemented in clinical practice. Prescription data were collected across three phases: pre-intervention, post-DDSI list implementation, and post-drug information intervention. Results: The DDSI list included 39 active ingredients across 7 ATC groups, with 128 clinically significant contraindicated interactions. The DDSI rate decreased significantly from 0.108% pre-intervention to 0.062% after list implementation and further to 0.0045% after drug information provision (p < 0.001). Conclusions: Drug information provision combined with a DDSI list significantly reduced DDSI occurrence in prescribing practice and represents a feasible approach in settings without clinical decision support systems.