Two Different Profiles for Packaging RNA inside Viruses

Tran Thanh Tuyen, Nguyen Van Khanh, Nguyen Van Thuy, Vu Van Quyen, Nguyen The Toan

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Published Jun 15, 2016

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TUYEN, Tran Thanh et al. Two Different Profiles for Packaging RNA inside Viruses. VNU Journal of Science: Mathematics - Physics, [S.l.], v. 32, n. 2, june 2016. ISSN 2588-1124. Available at: <https://js.vnu.edu.vn/MaP/article/view/1692>. Date accessed: 29 dec. 2024.
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Issue
Vol 32 No 2
Section
Review Article

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Abstract

Abstract: The problem of RNA genomes packaged inside spherical viruses is studied. The viral capsid is modeled as a hollowed sphere. The attraction between RNA molecules and the inner viral capsid is assumed to be non-specific and occurs at the inner capsid surface only. For small capsid attraction, it is found that monomer concentration of RNA molecules is maximal at the center of the capsid to maximize their configurational entropy. For stronger capsid attraction, RNA concentration peaks at some distance near the capsid. In the latter case, the competition between the branching of RNA secondary structure and its adsorption to the inner capsid results in the formation of a dense layer of RNA near capsid surface. The layer thickness is a slowly varying (logarithmic) function of the capsid inner radius. Consequently, for immediate strength of RNA-capsid interaction, the amount of RNA packaged inside a virus is proportional to the capsid area (or the number of proteins) instead of its volume. The numerical profiles describe reasonably well the experimentally observed RNA nucleotide concentration profiles of various viruses.

Keywords: RNA viruses, RNA condensation, viral RNA packaging, RNA structure.

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