Hanh Hong Mai

Main Article Content


In this work, biomaterial based microlasers were successfully fabricated by a cost effective, simple and environmental friendly fabrication method. The as-fabricated microlasers were made of biocompatible material including ovalbumin doped Rhodamine B at low weight percentage. The lasers had solid-state spheres with various diameters ranging from 20 µm to over 100 µm. It was shown that inside the spherical cavity which supported whispering gallery mode, a lasing emission was generated with a low threshold of 17.5 µJ/mm2, and a high Q-factor of approximately 3000. The remarkable lasing properties of the dye doped ovalbumin microlasers are considered as important bases for their future biological and medical applications.

Keywords: Microlasers, ovalbumin, whispering gallery mode.


[1] V.D. Ta, Y. Wang, H. Sun, Microlasers Enabled by Soft‐Matter Technology, Adv. Opt. Mater. 7 (2019) 1900057. https://doi.org/10.1002/adom.201900057.
[2] Y. Chen, X. Fan, Biological Lasers for Biomedical Applications, Adv. Opt. Mater. 7 (2019) 1900377. https://doi.org/10.1002/adom.201900377.
[3] V.D. Ta, S. Caixeiro, F.M. Fernandes, R. Sapienza, Microsphere Solid-State Biolasers, Adv. Opt. Mater. 5 (2017) 1–6. https://doi.org/10.1002/adom.201601022.
[4] M. Humar, A. Dobravec, X. Zhao, S.H. Yun, Biomaterial microlasers implantable in the cornea, skin, and blood, Optica. 4 (2017) 1080 - 1085. https://doi.org/10.1364/optica.4.001080.
[5] Y.L. Sun, Z.S. Hou, S.M. Sun, B.Y. Zheng, J.F. Ku, W.F. Dong, Q.D. Chen, H.B. Sun, Protein-Based Three-Dimensional Whispering-Gallery-Mode Micro-Lasers with Stimulus-Responsiveness, Sci. Rep. 5 (2015) 1–14. https://doi.org/10.1038/srep12852.
[6] J. Kovacs-Nolan, M. Phillips, Y. Mine, Advances in the Value of Eggs and Egg Components for Human Health, J. Agric. Food Chem. 53 (2005) 8421–8431. https://doi.org/10.1021/jf050964f.
[7] X. Wang, M. Bao, J. Wu, Y. Luo, L. Ma, Y. Wang, A. Zhang, C. He, H. Zhang, Characterization and Comparison of Ochratoxin A-Ovalbumin (OTA-OVA) Conjugation by Three Methods, J. Integr. Agric. 13 (2014) 1130–1136. https://doi.org/10.1016/S2095-3119(14)60767-X.
[8] S. Caixeiro, M. Gaio, B. Marelli, F.G. Omenetto, R. Sapienza, Silk-Based Biocompatible Random Lasing, Adv. Opt. Mater. 4 (2016) 998–1003. https://doi.org/10.1002/adom.201600185.
[9] C.S. Wang, T.Y. Chang, T.Y. Lin, Y.F. Chen, Biologically inspired flexible quasi-single-mode random laser: An integration of Pieris canidia butterfly wing and semiconductors, Sci. Rep. 4 (2014) 1–6. https://doi.org/10.1038/srep06736.
[10] D.S. Wiersma, Disordered photonics, Nat. Photonics. 7 (2013) 188–196. https://doi.org/10.1038/nphoton.2013.29.
[11] R.R. Da Silva, C.T. Dominguez, M. V. Dos Santos, R. Barbosa-Silva, M. Cavicchioli, L.M. Christovan, L.S.A. De Melo, A.S.L. Gomes, C.B. De Araújo, S.J.L. Ribeiro, Silk fibroin biopolymer films as efficient hosts for DFB laser operation, J. Mater. Chem. C. 1 (2013) 7181–7190. https://doi.org/10.1039/c3tc30903g.
[12] M.C. Gather, S.H. Yun, Single-cell biological lasers, Nat. Photonics. 5 (2011) 406–410. https://doi.org/10.1038/nphoton.2011.99.
[13] T. Reynolds, N. Riesen, A. Meldrum, X. Fan, J.M.M. Hall, T.M. Monro, A. François, Fluorescent and lasing whispering gallery mode microresonators for sensing applications, Laser Photonics Rev. 11 (2017) 1–20. https://doi.org/10.1002/lpor.201600265.
[14] V. Duong Ta, R. Chen, L. Ma, Y. Jun Ying, H. Dong Sun, Whispering gallery mode microlasers and refractive index sensing based on single polymer fiber, Laser Photonics Rev. 7 (2013) 133–139. https://doi.org/10.1002/lpor.201200074.
[15] M. Humar, S.H. Yun, Intracellular microlasers, Nat. Photonics. 9 (2015) 572–576. https://doi.org/10.1038/nphoton.2015.129.
[16] M. Schubert, A. Steude, P. Liehm, N.M. Kronenberg, M. Karl, E.C. Campbell, S.J. Powis, M.C. Gather, Lasing within Live Cells Containing Intracellular Optical Microresonators for Barcode-Type Cell Tagging and Tracking, Nano Lett. 15 (2015) 5647–5652. https://doi.org/10.1021/acs.nanolett.5b02491.
[17] M.C. Gather, S.H. Yun, Bio-optimized energy transfer in densely packed fluorescent protein enables near-maximal luminescence and solid-state lasers, Nat. Commun. 5 (2014) 1–8. https://doi.org/10.1038/ncomms6722.
[18] R. Chen, V.D Ta, H.D. Sun, Single mode lasing from hybrid hemispherical microresonators, Sci. Rep. 2 (2012) 244. https://doi.org/10.1038/srep00244.
[19] C.C. Lam, P.T. Leung, K. Young, Explicit asymptotic formulas for the positions, widths, and strengths of resonances in Mie scattering, J. Opt. Soc. Am. B. 9 (1992) 1585 - 1592. https://doi.org/10.1364/JOSAB.9.001585.